NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer Journal Article


Authors: Nakada, T.; Noguchi, Y.; Satoh, S.; Ono, T.; Saika, T.; Kurashige, T.; Gnjatic, S.; Ritter, G.; Chen, Y. T.; Stockert, E.; Nasu, Y.; Tsushima, T.; Kumon, H.; Old, L. J.; Nakayama, E.
Article Title: NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer
Abstract: NY-ESO-1 mRNA expression was investigated in advanced prostate cancer by conventional and quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR). NY-ESO-1 mRNA was detected in 20 of 53 (38%) tumor specimens. Four of 15 (27%) stage C, 1 of 3 stage D1 (33%) and 15 of 35 (43%) stage D2 prostate cancers were positive. The presence of NY-ESO-1 antibodies was evaluated in sera from a panel of 218 patients with prostate cancer, including the 53 patients whose tumors were examined for NY-ESO-1 mRNA expression. NY-ESO-1 antibodies were detected in 1 of 30 (3.3%) stage D1 and 9 of 110 (8.2%) stage D2 patients, whereas none of the 78 patients with localized prostate cancer (stages A, B and C) had detectable NY-ESO-1 antibodies. Of the 53 patients whose tumors were examined for NY-ESO-1 mRNA expression, 2 of 20 patients with NY-ESO-1 mRNA-positive tumors had NY-ESO-1 antibodies. No antibody was found in the sera of 32 patients with NY-ESO-1 mRNA-negative tumors, with the exception of one patient with regional lymph node metastasis (stage D1). CD8 T cell responses specific to NY-ESO-1 were detected in two of three patients with NY-ESO-1 antibodies.
Keywords: adult; controlled study; human tissue; aged; unclassified drug; major clinical study; clinical feature; cancer staging; antigen expression; t lymphocyte; reverse transcription polymerase chain reaction; prostate cancer; gamma interferon; messenger rna; cancer testis antigen; ny eso 1 antigen; antigen detection; immunogenicity; antibody response; prostate hypertrophy; immunity; antibody detection; mrna; rt-pcr; cancer antibody; ny-eso-1; ny eso 1 antibody; human; male; article
Journal Title: Cancer Immunity
Volume: 3
ISSN: 1424-9634
Publisher: Academy of Cancer Immunology  
Date Published: 2003-07-31
Start Page: 10
Language: English
PROVIDER: scopus
PUBMED: 12889868
DOI/URL:
Notes: Export Date: 12 September 2014 -- Source: Scopus
Citation Impact
MSK Authors
  1. Sacha Gnjatic
    113 Gnjatic
  2. Gerd Ritter
    166 Ritter
  3. Lloyd J Old
    593 Old
  4. Yao-Tseng Chen
    83 Chen