Synthetic carbohydrate-based antitumor vaccines Book Section
| Authors: | Wilson, R. M.; Warren, J. D.; Ouerfelli, O.; Danishefsky, S. J. |
| Editor: | Roy, R. |
| Article/Chapter Title: | Synthetic carbohydrate-based antitumor vaccines |
| Title Series: | ACS Symposium Series |
| Abstract: | Our laboratory has a longstanding program devoted to the preparation and immunological evaluation of fully synthetic carbohydrate-based antitumor vaccine constructs. We present herein a brief historical account of the evolution of this research program, and describe key achievements, including the synthesis of the Globo-H-KLH construct, which is currently in clinical trials. Remarkable advances in carbohydrate and glycopeptide assembly techniques have allowed for the synthesis of increasingly sophisticated, structurally complex vaccine constructs. In this setting, we have successfully accomplished the synthesis of a highly complex unimolecular pentavalent vaccine construct, in which five prostate and breast cancer-associated carbohydrate antigens are displayed on a single polypeptide backbone. © 2008 American Chemical Society. |
| Keywords: | clinical trial; anti-tumors; carbohydrates; glycopeptides; vaccines; unimolecular; assembly techniques; historical account; polypeptide backbones; research programs |
| Book Title: | Carbohydrate-Based Vaccines |
| Volume: | 989 |
| ISBN: | 978-0-8412-3983-8 |
| Publisher: | American Chemical Society |
| Publication Place: | [Washington, DC] |
| Date Published: | 2008-07-02 |
| Start Page: | 258 |
| End Page: | 292 |
| Language: | English |
| DOI: | 10.1021/bk-2008-0989.ch012 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter 12 -- Cited By (since 1996):2 -- Export Date: 2 September 2014 -- CODEN: ACSMC -- Source: Scopus |
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