Synthetic carbohydrate-based anticancer vaccines: The Memorial Sloan-Kettering experience Journal Article
| Authors: | Zhu, J.; Warren, J. D.; Danishefsky, S. J. |
| Article Title: | Synthetic carbohydrate-based anticancer vaccines: The Memorial Sloan-Kettering experience |
| Abstract: | Malignantly transformed cells can express aberrant cell surface glycosylation patterns, which serve to distinguish them from normal cells. This phenotype provides an opportunity for the development of carbohydrate-based vaccines for cancer immunotherapy. Synthetic carbohydrate-based vaccines, properly introduced through vaccination of a subject with a suitable construct, should be recognized by the immune system. Antibodies induced against these carbohydrate antigens could then participate in the eradication of carbohydrate-displaying tumor cells. Advances in carbohydrate synthetic capabilities have allowed us to efficiently prepare a range of complex, synthetic anticancer vaccine candidates. We describe herein the progression of our longstanding carbohydrate-based anticancer vaccine program, which is now at the threshold of clinical evaluation in several contexts. Our carbohydrate-based anticancer vaccine program has evolved through a number of stages: monomeric vaccines, monomeric clustered vaccines, unimolecular multi-antigenic vaccines and dual-acting vaccines. This account will focus on our recently developed unimolecular multi-antigenic constructs and potential dual-acting constructs, which contain clusters of both carbohydrate and peptide epitopes. © 2009 Expert Reviews Ltd. |
| Keywords: | clinical trial; review; nonhuman; neoplasms; antigen expression; animals; cancer immunotherapy; ovary cancer; peritoneum cancer; breast cancer; lung non small cell cancer; drug structure; drug design; drug synthesis; structure-activity relationship; enzyme linked immunosorbent assay; prostate cancer; lung small cell cancer; immune response; immunotherapy; cancer vaccine; cancer vaccines; immunogenicity; cancer cell; antibody response; vaccination; epitope; ganglioside gm1; mucin 1; program development; antibodies; fluorescence activated cell sorting; antibody; ganglioside gm2; antigens, tumor-associated, carbohydrate; carbohydrate antigen; antibody titer; keyhole limpet hemocyanin; mucin; oligosaccharide; triple vaccine; anticancer vaccine; glycoconjugate; gtycopeptide; mucin 2; carbohydrate conformation; epitopes |
| Journal Title: | Expert Review of Vaccines |
| Volume: | 8 |
| Issue: | 10 |
| ISSN: | 1476-0584 |
| Publisher: | Informa Healthcare |
| Date Published: | 2009-10-01 |
| Start Page: | 1399 |
| End Page: | 1413 |
| Language: | English |
| DOI: | 10.1586/erv.09.95 |
| PUBMED: | 19803761 |
| PROVIDER: | scopus |
| PMCID: | PMC3063993 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ERVXA" - "Source: Scopus" |
