Synthetic carbohydrate-based antitumor vaccines: Challenges and opportunities Journal Article

  


Authors: Ouerfelli, O.; Warren, J. D.; Wilson, R. M.; Danishefsky, S. J.
Article Title: Synthetic carbohydrate-based antitumor vaccines: Challenges and opportunities
Abstract: The development of a clinically effective, carbohydrate-based antitumor vaccine is a longstanding ambition in the prevention and treatment of cancer. This review seeks to provide a discussion of some of the unique challenges facing this particular field of immunology. The authors present a historic account of their ongoing research program devoted to the development of fully synthetic, carbohydrate-based anticancer vaccines of clinical value. As will be seen, remarkable advances in carbohydrate and glycopeptide assembly techniques have allowed for the preparation of synthetic constructs of progressively increasing structural complexity. The authors describe the evolution of their synthetic carbohydrate program from first-generation constructs, which were monovalent in nature, to highly complex unimolecular multivalent vaccines, in which multiple carbohydrate antigens are displayed in the context of a single polypeptide backbone. It is the hope that each generation of vaccines represents a move closer to achieving the ultimate objective of developing broadly useful, robust anticancer vaccines. © 2005 Future Drugs Ltd.
Keywords: unclassified drug; clinical trial; review; drug efficacy; nonhuman; cancer patient; animals; protein assembly; drug structure; drug screening; drug discovery; drug evaluation, preclinical; drug design; drug synthesis; breast neoplasms; prostatic neoplasms; drug research; immune response; cancer vaccine; cancer vaccines; immunogenicity; antibody response; drug response; vaccines, synthetic; mucin 1; antibody; drug conjugation; clinical trials; antigens, tumor-associated, carbohydrate; carbohydrate sequence; carbohydrates; glycopeptide; glycopeptides; carbohydrate; vaccines; keyhole limpet hemocyanin; history of medicine; vaccines, conjugate; triple vaccine; globo h antigen; mucin 2; cancer immunology; tumor therapy; mutiantigenic glycoconjugate; fucosyl gm1 antigen; fucosyl gm2 antigen; lewisy antigen
Journal Title: Expert Review of Vaccines
Volume: 4
Issue: 5
ISSN: 1476-0584
Publisher: Informa Healthcare  
Date Published: 2005-10-01
Start Page: 677
End Page: 685
Language: English
DOI: 10.1586/14760584.4.5.677
PUBMED: 16221069
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-27444441764&partnerID=40&md5=c84937b2d1c1b551d9e686680d7a54cd
Notes: --- - "Cited By (since 1996): 41" - "Export Date: 24 October 2012" - "CODEN: ERVXA" - "Source: Scopus"
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Ouathek Ouerfelli
    100 Ouerfelli
  3. Rebecca Wilson
    17 Wilson
  4. James D Warren
    8 Warren
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