A vision for vaccines built from fully synthetic tumor-associated antigens: From the laboratory to the clinic Journal Article

   


Authors: Wilson, R. M.; Danishefsky, S. J.
Article Title: A vision for vaccines built from fully synthetic tumor-associated antigens: From the laboratory to the clinic
Abstract: Cancer cells may be distinguished from normal cells by cell surface displays of aberrant levels and types of carbohydrate domains. Accordingly, these tumor-associated carbohydrate antigens (TACAs) represent promising target structures for the design of anticancer vaccines. Over the past 20 years, our laboratory has sought to use the tools of chemical synthesis to develop TACA-based anticancer vaccine candidates. We provide herein a personal accounting of our laboratory's progress toward the long-standing goal of developing clinically viable fully synthetic carbohydrate-based anticancer vaccines. © 2013 American Chemical Society.
Journal Title: Journal of the American Chemical Society
Volume: 135
Issue: 39
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2013-10-02
Start Page: 14462
End Page: 14472
Language: English
DOI: 10.1021/ja405932r
PROVIDER: scopus
PMCID: PMC3826082
PUBMED: 23944352
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84885105341&partnerID=40&md5=917cd9d74fb93590c66548070255486d
Notes: --- - "Export Date: 1 November 2013" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Rebecca Wilson
    17 Wilson
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