Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: A synthetic route to anticancer vaccine candidates Journal Article

  


Authors: Ragupathi, G.; Koide, F.; Livingston, P. O.; Cho, Y. S.; Endo, A.; Wan, Q.; Spassova, M. K.; Keding, S. J.; Allen, J.; Ouerfelli, O.; Wilson, R. M.; Danishefsky, S. J.
Article Title: Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: A synthetic route to anticancer vaccine candidates
Abstract: Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein. © 2006 American Chemical Society.
Keywords: controlled study; nonhuman; animal cell; mouse; animals; mice; animal tissue; breast cancer; animal experiment; animal model; antineoplastic activity; cell line, tumor; breast neoplasms; prostate cancer; prostatic neoplasms; immunology; molecular sequence data; antigens; antigens, neoplasm; cancer vaccine; cancer vaccines; tumors; antigen detection; peptides; target cell; amino acids; vaccine production; ganglioside gm2; synthesis (chemical); carbohydrate sequence; carbohydrates; vaccines; sialic acids; carbohydrate derivative; hemocyanin; glycosides; oligosaccharide; polypeptides; oligosaccharides; carbohydrate-based antitumor vaccines; sialic acid; immunological procedures; g(m2) ganglioside
Journal Title: Journal of the American Chemical Society
Volume: 128
Issue: 8
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2006-03-01
Start Page: 2715
End Page: 2725
Language: English
DOI: 10.1021/ja057244+
PUBMED: 16492059
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33644650565&partnerID=40&md5=374d3cbe75f200fe8c0ba473aec0fbaa
Notes: --- - "Cited By (since 1996): 65" - "Export Date: 4 June 2012" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Atsushi Endo
    5 Endo
  2. Stacy J Keding
    9 Keding
  3. Young Shin Cho
    12 Cho
  4. Fusataka Koide
    14 Koide
  5. Jennifer R Allen
    11 Allen
  6. Qian Wan
    23 Wan
  7. Govindaswami Ragupathi
    144 Ragupathi
  8. Samuel J Danishefsky
    539 Danishefsky
  9. Ouathek Ouerfelli
    100 Ouerfelli
  10. Maria K Spassova
    25 Spassova
  11. Philip O Livingston
    228 Livingston
  12. Rebecca Wilson
    17 Wilson
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