Fatigue and functional impairment in early-stage non-small cell lung cancer survivors Journal Article
| Authors: | Hung, R.; Krebs, P.; Coups, E. J.; Feinstein, M. B.; Park, B. J.; Burkhalter, J.; Ostroff, J. S. |
| Article Title: | Fatigue and functional impairment in early-stage non-small cell lung cancer survivors |
| Abstract: | Context: Fatigue is the most common sequela among non-small cell lung cancer (NSCLC) survivors one to six years post-treatment and is associated with functional limitations. Objectives: This study examined the prevalence, severity, and correlates of fatigue among early stage NSCLC survivors. Methods: Three-hundred fifty individuals diagnosed and surgically treated for Stage IA or IB NSCLC completed a survey that included the Brief Fatigue Inventory (BFI) to assess the prevalence and severity of fatigue. The Karnofsky Self-Reported Performance Rating scale (SR-KPS) was used as a measure of functional status and was compared with the severity of fatigue through Chi-squared analyses. Demographic, psychological, and medical correlates of fatigue were examined using logistic regression. Results: The prevalence of fatigue was 57%. Forty-one percent (n = 142) of participants had mild fatigue and 16.8% (n = 59) had moderate or severe fatigue (BFI ≥ 4). Among the individuals reporting moderate or severe fatigue, 23.7% (n = 14) had significant functional impairment (SR-KPS ≤ 70%) compared with 2.8% (n = 8) with mild or no fatigue (χ2 = 58.1, P < 0.001). In the multivariate analysis, NSCLC survivors with pulmonary disease (odds ratio [OR] = 2.28), depressive symptoms (OR = 6.99), and anxiety symptoms (OR = 2.31) were more likely to report experiencing clinically significant fatigue, whereas those who met physical activity guidelines (OR = 0.29) reported less fatigue. Conclusion: Fatigue is highly prevalent among NSCLC survivors and associated with more functional impairment. A comprehensive approach to the treatment of fatigue includes the screening and management of anxious and depressive symptoms, and pulmonary disorders such as chronic obstructive pulmonary disease. © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved. |
| Keywords: | adult; aged; major clinical study; fatigue; cancer staging; lung non small cell cancer; prevalence; cancer survivor; self report; dyspnea; depression; disease severity; cancer fatigue; anxiety; physical activity; functional disease; functional impairment; lung cancer survivor; non-small cell lung cancer survivor; symptom cluster |
| Journal Title: | Journal of Pain and Symptom Management |
| Volume: | 41 |
| Issue: | 2 |
| ISSN: | 0885-3924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-02-01 |
| Start Page: | 426 |
| End Page: | 435 |
| Language: | English |
| DOI: | 10.1016/j.jpainsymman.2010.05.017 |
| PROVIDER: | scopus |
| PMCID: | PMC3063865 |
| PUBMED: | 21216563 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: JPSME" - "Source: Scopus" |
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