Health-related quality of life in cancer survivors with chemotherapy-induced peripheral neuropathy: A randomized clinical trial Journal Article
| Authors: | Bao, T.; Baser, R.; Chen, C.; Weitzman, M.; Zhang, Y. L.; Seluzicki, C.; Li, Q. S.; Piulson, L.; Zhi, W. I. |
| Article Title: | Health-related quality of life in cancer survivors with chemotherapy-induced peripheral neuropathy: A randomized clinical trial |
| Abstract: | Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating adverse effect of neurotoxic chemotherapy that significantly worsens the quality of life of cancer survivors. Materials and Methods: Survivors of solid tumors with persistent moderate-to-severe CIPN defined as numbness, tingling, or pain rated ≥4 on an 11-point numeric rating scale (NRS) were randomized in a 1:1:1 ratio to 8 weeks of real acupuncture (RA) versus sham acupuncture (SA) versus usual care (UC). We previously reported the primary endpoint (NRS); here we report the following health-related quality of life endpoints: Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), and Brief Fatigue Inventory (BFI). For each endpoint, the mean changes from baseline and 95% confidence intervals were estimated within each arm and compared between arms using linear mixed models. Results: We enrolled 75 survivors of solid tumors with moderate-to-severe CIPN into the study. Compared with baseline, at week 8, FACT/GOG-Ntx, HADS anxiety, and ISI scores significantly improved in RA and SA, but not in UC. Compared with UC, at week 8, FACT/GOG-Ntx scores significantly increased in RA and SA arms indicating improved CIPN-related symptoms and quality of life (p =.001 and p =.01). There was no statistically significant difference between RA and SA. There was no difference in HADS depression or BFI among RA, SA, and UC at weeks 8 and 12. Conclusion: Acupuncture may improve CIPN-related symptoms and quality of life in cancer survivors with persistent CIPN. Further large sample size studies are needed to delineate placebo effects. Implications for Practice: The authors conducted a randomized sham acupuncture- and usual care-controlled clinical trial to evaluate the impact of acupuncture on health-related quality of life outcomes in patients with solid tumors with chemotherapy-induced peripheral neuropathy (CIPN). Statistically significant improvements in quality of life, anxiety, insomnia, and fatigue were achieved with 8 weeks of real acupuncture when compared with baseline, without statistically significant differences between real and sham acupuncture. These findings suggest that acupuncture may be effective for improving CIPN-related symptoms and quality of life and reducing anxiety and insomnia in cancer survivors with persistent CIPN, with further study needed to delineate placebo effects. © 2021 AlphaMed Press. |
| Keywords: | adult; middle aged; major clinical study; paresthesia; quality of life; pain; neuropathy; randomized controlled trial; cancer survivor; questionnaire; insomnia; patient compliance; distress syndrome; platinum; acupuncture; anxiety; taxane derivative; chemotherapy-induced peripheral neuropathy; hospital anxiety and depression scale; contusion; skin tingling; claustrophobia; cancer; human; male; female; article; numeric rating scale; insomnia severity index; solid malignant neoplasm; functional assessment of cancer therapy cognitive function; big five inventory |
| Journal Title: | The Oncologist |
| Volume: | 26 |
| Issue: | 11 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2021-11-01 |
| Start Page: | e2070 |
| End Page: | e2078 |
| Language: | English |
| DOI: | 10.1002/onco.13933 |
| PUBMED: | 34390283 |
| PROVIDER: | scopus |
| PMCID: | PMC8571772 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2021 -- Source: Scopus |
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