Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: Prevalence, risk factors, and fall risk Journal Article


Authors: Bao, T.; Basal, C.; Seluzicki, C.; Li, S. Q.; Seidman, A. D.; Mao, J. J.
Article Title: Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: Prevalence, risk factors, and fall risk
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity associated with chemotherapy, but researchers rarely study its risk factors, fall risk, and prevalence in long-term breast cancer survivors. We aimed to determine CIPN prevalence, risk factors, and association with psychological distress and falls among long-term breast cancer survivors. We conducted Cross-sectional analyses among postmenopausal women with a history of stage I–III breast cancer who received taxane-based chemotherapy. Participants reported neuropathic symptoms of tingling/numbness in hands and/or feet on a 0–10 numerical rating scale. We conducted multivariate logistic regression analyses to evaluate risk factors associated with the presence of CIPN and the relationship between CIPN and anxiety, depression, insomnia, and patient-reported falls. Among 296 participants, 173 (58.4 %) reported CIPN symptoms, 91 (30.7 %) rated their symptoms as mild, and 82 (27.7 %) rated them moderate to severe. Compared with women of normal weight, being obese was associated with increased risk of CIPN (adjusted OR 1.94, 95 % CI: 1.03–3.65). Patients with CIPN reported greater insomnia severity, anxiety, and depression than those without (all p < 0.05). Severity of CIPN was associated with higher rates of falls, with 23.8, 31.9, and 41.5 % in the “no CIPN,” “mild,” and “moderate-to-severe” groups, respectively, experiencing falls (p = 0.028). The majority of long-term breast cancer survivors who received taxane-based chemotherapy reported CIPN symptoms; obesity was a significant risk factor. Those with CIPN also reported increased psychological distress and falls. Interventions need to target CIPN and comorbid psychological symptoms, and incorporate fall prevention strategies for aging breast cancer survivors. © 2016, Springer Science+Business Media New York.
Keywords: chemotherapy; breast cancer; peripheral neuropathy; obesity; falls
Journal Title: Breast Cancer Research and Treatment
Volume: 159
Issue: 2
ISSN: 0167-6806
Publisher: Springer  
Date Published: 2016-09-01
Start Page: 327
End Page: 333
Language: English
DOI: 10.1007/s10549-016-3939-0
PROVIDER: scopus
PUBMED: 27510185
PMCID: PMC5509538
DOI/URL:
Notes: Qing Susan Li's first and middle names are reversed on the original publication -- Article -- Export Date: 3 October 2016 -- Source: Scopus
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MSK Authors
  1. Andrew D Seidman
    290 Seidman
  2. Ting   Bao
    50 Bao
  3. Jun J Mao
    135 Mao
  4. Coby R Basal
    2 Basal
  5. Qing Susan Li
    50 Li