Current sunscreen controversies: A critical review Journal Article


Authors: Burnett, M. E.; Wang, S. Q.
Article Title: Current sunscreen controversies: A critical review
Abstract: Sunscreens are believed to be a valuable tool in providing photoprotection against the detrimental effects of UV radiation, a known carcinogen. However, a number of controversies have developed regarding their safety and efficacy. This review summarizes the relevant studies surrounding these controversies. Methods: Evidence of the prevention of skin cancer, an oft-cited reason for sunscreen use, was examined as it pertains to squamous cell carcinoma, basal cell carcinoma and melanoma. We also reviewed studies examining the effects of sunscreen on the synthesis of vitamin D, an essential nutrient whose role in health and disease continues to grow. Lastly, we analyzed studies surrounding the safety and toxicity of oxybenzone, retinyl palmitate and nanoparticles of zinc oxide (ZnO) and titanium dioxide (TiO2). Results: The overwhelming majority of available data is drawn from studies conducted using antiquated sunscreen formulations. Nonetheless, our research revealed that topical use of sunscreen protects against squamous cell carcinoma, does not cause vitamin D deficiency/insufficiency in practice and has not been demonstrated to adversely affect the health of humans. Conclusion: Given the established benefits of UV protection, the use of sunscreens remains an important part of an overall photoprotective strategy. Future sunscreens with improved formulation should ideally offer superior protection. With increased usage of sunscreen by the public, continuous and vigilant monitoring of the overall safety of future products is also needed. © 2011 John Wiley & Sons A/S.
Keywords: review; squamous cell carcinoma; drug efficacy; drug safety; nonhuman; unspecified side effect; drug megadose; ultraviolet radiation; sunscreen; melanoma; basal cell carcinoma; sun exposure; skin cancer; in vivo study; in vitro study; vitamin d; nanoparticles; nanoparticle; vitamin d deficiency; drug absorption; retinol; ultraviolet b radiation; retinoid; vitamin blood level; oxybenzone; titanium dioxide; zinc oxide; retinyl palmitate; retinol palmitate
Journal Title: Photodermatology Photoimmunology and Photomedicine
Volume: 27
Issue: 2
ISSN: 0905-4383
Publisher: Blackwell Publishing  
Date Published: 2011-04-01
Start Page: 58
End Page: 67
Language: English
DOI: 10.1111/j.1600-0781.2011.00557.x
PROVIDER: scopus
PUBMED: 21392107
DOI/URL:
Notes: --- - "Export Date: 23 June 2011" - "CODEN: PPPHE" - "Source: Scopus"
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MSK Authors
  1. Steven Q Wang
    73 Wang
  2. Mark Burnett
    12 Burnett
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