Radiofrequency ablation of T1 lung carcinoma: Comparison of outcomes for first primary, metachronous, and synchronous lung tumors Journal Article
| Authors: | Ridge, C. A.; Silk, M.; Petre, E. N.; Erinjeri, J. P.; Alago, W.; Downey, R. J.; Sofocleous, C. T.; Thornton, R. H.; Solomon, S. B. |
| Article Title: | Radiofrequency ablation of T1 lung carcinoma: Comparison of outcomes for first primary, metachronous, and synchronous lung tumors |
| Abstract: | Purpose: To report and compare outcomes after radiofrequency ablation for treatment-naïve first primary, metachronous, and synchronous T1 lung tumors. Materials and Methods: This institutional review board-approved retrospective study reviewed 29 patients (12 men and 17 women; median age, 73 y; age range, 55-86 y) with treatment-naïve T1 lung tumors treated with radiofrequency ablation. Tumors in the 29 patients included 21 T1a and 8 T1b first primary (n = 11), metachronous (n = 14), or synchronous (n = 4) tumors (adenocarcinoma, n = 25; squamous cell carcinoma, n = 3; unspecified, n = 1). Median tumor diameter was 14 mm (range, 10-26 mm). Surveillance computed tomography or positron emission tomography-computed tomography was performed over a median period of 28 months (range, 12-83 mo). Technical success and effectiveness rates and overall and progression-free 1-year, 3-year, and 5-year survivals were calculated according to stage, first primary, metachronous, and synchronous tumor status. Results: Technical success and effectiveness was 97%. Local control occurred in 17 of 21 T1a tumors (81%) and 5 of 8 T1b tumors (62.5%). The local progression rate of first primary tumors (5 of 11; 45%) was higher than that of metachronous (2 of 14; 14%; P =.07) and synchronous (0 of 4; P =.01) tumors. Estimated 1-year, 3-year, and 5-year local tumor progression-free survival was 79%, 75%, and 75%. Estimated 1-year, 3-year, and 5-year overall survival was 100%, 60%, and 14%. Survival outcomes were similar for patients with first primary, metachronous, or synchronous tumors. Conclusions: Radiofrequency ablation results in good local control and progression-free survival in patients with treatment-naïve T1 lung tumors, including patients with metachronous and synchronous tumors. © 2014 SIR. |
| Keywords: | adult; clinical article; treatment outcome; aged; overall survival; cancer patient; comparative study; cancer staging; progression free survival; computer assisted tomography; tumor volume; lung non small cell cancer; lung adenocarcinoma; computer assisted emission tomography; lung squamous cell carcinoma; cancer control; radiofrequency ablation; computed tomography scanner; human; male; female; priority journal; article; radiofrequency ablation device |
| Journal Title: | Journal of Vascular and Interventional Radiology |
| Volume: | 25 |
| Issue: | 7 |
| ISSN: | 1051-0443 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2014-07-01 |
| Start Page: | 989 |
| End Page: | 996 |
| Language: | English |
| DOI: | 10.1016/j.jvir.2014.02.021 |
| PROVIDER: | scopus |
| PUBMED: | 24703321 |
| DOI/URL: | |
| Notes: | Export Date: 1 August 2014 -- CODEN: JVIRE -- Source: Scopus |
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