Multiple primary lung carcinomas: Prognosis and treatment Journal Article
| Authors: | Rosengart, T. K.; Martini, N.; Ghosn, P.; Burt, M. |
| Article Title: | Multiple primary lung carcinomas: Prognosis and treatment |
| Abstract: | From 1955 to 1990, 111 patients have been treated for multiple primary lung carcinomas. Criteria for diagnosis were: (1) different histology (n = 44); or (2) same histology, but disease-free interval at least 2 years (n = 39), origin from carcinoma in situ (n = 19), or metachronous disease in different lobe (n = 9) with no cancer in common lymphatics or extrapulmonary metastasis at the time of diagnosis. The second cancer was synchronous in 33 patients (30%) and metachronous in 78 (70%). Metachronous disease developed at a median interval of 48 months. Five-year survival for patients with metachronous and synchronous disease from the time of initial diagnosis of cancer was 70% and 44%, and 10-year survival was 42% and 23%, respectively. Survival after the development of a metachronous lesion was 23% at 5 years. Survival from the time of initial diagnosis was significantly better for metachronous versus synchronous, late (24 month disease-free interval) versus early metachronous disease, and adenocarcinema versus epidermoid carcinoma. The first cancer was completely resected in 103 patients (93%), but complete resection of a metachronous tumor was possible in only 54 patients (69%). Complete resection of second primary cancers resulted in significantly (p < 0.0001) prolonged 5-year survival compared with incomplete resection (38% versus 9%). Excluding patients requiring pneumonectomy, initial resection limited subsequent resection in only 7 patients (9%) with metachronous disease. We conclude that patients surviving treatment of primary lung cancers require lifelong screening for multiple primary lung carcinoma, and complete resection is recommended whenever possible. © 1991. |
| Keywords: | adult; aged; major clinical study; conference paper; lung neoplasms; lung carcinoma; neoplasms, second primary; neoplasms, multiple primary; middle age; prognosis; human; male; female; priority journal |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 52 |
| Issue: | 4 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1991-10-01 |
| Start Page: | 773 |
| End Page: | 779 |
| Language: | English |
| DOI: | 10.1016/0003-4975(91)91209-e |
| PUBMED: | 1929628 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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