Treatment of pulmonary colorectal metastases by radiofrequency ablation Journal Article
| Authors: | Petre, E. N.; Jia, X.; Thornton, R. H.; Sofocleous, C. T.; Alago, W.; Kemeny, N. E.; Solomon, S. B. |
| Article Title: | Treatment of pulmonary colorectal metastases by radiofrequency ablation |
| Abstract: | Background: Radiofrequency ablation has emerged as a potential, lung function-preserving treatment of colorectal lung metastases. Patients and Methods: Forty-five patients with colorectal pulmonary metastases underwent computed tomography-guided RFA from December 2004 to June 2010. A baseline posttreatment scan was obtained 4-6 weeks after RFA and follow-up imaging studies every 3 months thereafter were obtained and compared to evaluate the tumor progression at site of ablation or elsewhere. The primary end points were LTP-free survival and overall survival from RFA procedure. The Kaplan-Meier method was used to analyze the end points. A Cox proportional hazard model with robust inference was used to estimate the associations between baseline factors and survival end points. Results: Sixty-nine metastases were ablated in 45 patients. Tumor size ranged from 0.4 to 3.5 cm. The median number of metastases ablated per patient was 1 (range, 1-3). Median follow-up after RFA was 18 months. Median survival from the time of RFA was 46 months (95% confidence interval [CI], 27.8-47.3). One-, 2- and 3-year overall survival rates from the time of RFA were 95% (95% CI, 82%-99%), 72% (95% CI, 52%-85%), and 50% (95% CI, 26%-71%), respectively. Nine of 69 lesions (13%) progressed and 4 were retreated with no progression after second RFA. Median time to progression was not reached. LTP-free survival from RFA was 92% (95% CI, 82%-97%) at 1 year, 77% (95% CI, 58%-88%) at 2 years, and 77% (95% CI, 58%-88%) at 3 years. Conclusion: Radiofrequency ablation of lung metastases is an effective minimally invasive, parenchymal-sparing technique that has very good local control rates in patients with pulmonary metastases from colorectal cancer, with LTP-free survival of 77% at 3 years. © 2013 Elsevier Inc. All rights reserved. |
| Keywords: | colorectal cancer; radiofrequency ablation; local tumor control; pulmonary metastases |
| Journal Title: | Clinical Colorectal Cancer |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 1533-0028 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-03-01 |
| Start Page: | 37 |
| End Page: | 44 |
| Language: | English |
| DOI: | 10.1016/j.clcc.2012.07.003 |
| PROVIDER: | scopus |
| PUBMED: | 23026111 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 April 2013" - "CODEN: CCCLC" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work