Margin size is an independent predictor of local tumor progression after ablation of colon cancer liver metastases Journal Article
| Authors: | Wang, X.; Sofocleous, C. T.; Erinjeri, J. P.; Petre, E. N.; Gonen, M.; Do, K. G.; Brown, K. T.; Covey, A. M.; Brody, L. A.; Alago, W.; Thornton, R. H.; Kemeny, N. E.; Solomon, S. B. |
| Article Title: | Margin size is an independent predictor of local tumor progression after ablation of colon cancer liver metastases |
| Abstract: | Purpose: This study was designed to evaluate the relationship between the minimal margin size and local tumor progression (LTP) following CT-guided radiofrequency ablation (RFA) of colorectal cancer liver metastases (CLM). Methods: An institutional review board-approved, HIPPA-compliant review identified 73 patients with 94 previously untreated CLM that underwent RFA between March 2003 and May 2010, resulting in an ablation zone completely covering the tumor 4-8 weeks after RFA dynamic CT. Comparing the pre- with the post-RFA CT, the minimal margin size was categorized to 0, 1-5, 6-10, and 11-15 mm. Follow-up included CT every 2-4 months. Kaplan-Meier methodology and Cox regression analysis were used to evaluate the effect of the minimal margin size, tumor location, size, and proximity to a vessel on LTP. Results: Forty-five of 94 (47.9 %) CLM progressed locally. Median LTP-free survival (LPFS) was 16 months. Two-year LPFS rates for ablated CLM with minimal margin of 0, 1-5 mm, 6-10 mm, 11-15 mm were 26, 46, 74, and 80 % (p < 0.011). Minimal margin (p = 0.002) and tumor size (p = 0.028) were independent risk factors for LTP. The risk for LTP decreased by 46 % for each 5-mm increase in minimal margin size, whereas each additional 5-mm increase in tumor size increased the risk of LTP by 22 %. Conclusions: An ablation zone with a minimal margin uniformly larger than 5 mm 4-8 weeks postablation CT is associated with the best local tumor control. © 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). |
| Keywords: | radiofrequency ablation; ablation; local tumor progression; ablation margin evaluation method; colon cancer liver metastasis; ct guided; image guided; minimal margin |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 36 |
| Issue: | 1 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2013-02-01 |
| Start Page: | 166 |
| End Page: | 175 |
| Language: | English |
| DOI: | 10.1007/s00270-012-0377-1 |
| PROVIDER: | scopus |
| PUBMED: | 22535243 |
| PMCID: | PMC4122121 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2013" - "CODEN: CARAD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work