Mouse models of human cancer as tools in drug development Journal Article
| Author: | Holland, E. C. |
| Article Title: | Mouse models of human cancer as tools in drug development |
| Abstract: | Histologically accurate mouse models of human cancers generated by somatic or germline genetic modification strategies recapitulate the genetic alterations found in human tumors. In this issue of Cancer Cell, Romer et al. (2004) test a novel signaling inhibitor in a genetically defined mouse medulloblastoma and show the utility of these models in drug development. They demonstrate that targeting signaling components downstream of tumor initiating mutations can be an effective therapeutic strategy for solid tumors. |
| Keywords: | signal transduction; unclassified drug; gene mutation; histopathology; nonhuman; solid tumor; brain neoplasms; animals; mice; cell line; drug screening assays, antitumor; drug design; animalia; mice, transgenic; genetic engineering; xenograft; cell culture; medulloblastoma; tumor cell; neoplasms, experimental; cell migration; short survey; cyclopamine; disease models, animal; germ-line mutation; alkaloid; cancer; human; priority journal |
| Journal Title: | Cancer Cell |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2004-09-01 |
| Start Page: | 197 |
| End Page: | 198 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2004.09.004 |
| PUBMED: | 15380508 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):17 -- Export Date: 16 June 2014 -- CODEN: CCAEC -- Source: Scopus |
