Applications of mouse glioma models in preclinical trials Journal Article
| Authors: | Hu, X.; Holland, E. C. |
| Article Title: | Applications of mouse glioma models in preclinical trials |
| Abstract: | Gliomas are the most common primary tumors that arise from glial cells and their precursors in the central nervous system. Most of the genetic alterations identified in human gliomas result in signal transduction abnormalities or disruption of cell cycle arrest pathways. Over the past years, several mouse glioma models have been generated based on human genetic abnormalities and the induced gliomas exhibit histological similarities to their human counterparts. There is emerging evidence suggesting that an oncogenic signaling initiating tumorigenesis is also required for tumor maintenance, these glioma models can be used to further characterize the mechanisms of oncogenic signaling in tumor formation, as well as identify molecular targets in preclinical trials. |
| Keywords: | signal transduction; gene mutation; histopathology; review; nonhuman; glioma; brain neoplasms; animals; mice; cell cycle; astrocyte; drug evaluation, preclinical; central nervous system; carcinogenesis; cancer genetics; oncogene; glioblastoma; carcinogenicity; forecasting; glia cell; oligodendroglioma; tumor model; genetic disorder; cancer classification; tumor; disease models, animal; precursor; astrocytoma; oligodendroglia; microglia; gliomas; ependyma cell; oncogenic signalling |
| Journal Title: | Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume: | 576 |
| Issue: | 1-2 |
| ISSN: | 0027-5107 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2005-08-25 |
| Start Page: | 54 |
| End Page: | 65 |
| Language: | English |
| DOI: | 10.1016/j.mrfmmm.2004.08.023 |
| PUBMED: | 16011838 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 20" - "Export Date: 24 October 2012" - "CODEN: MRFME" - "Source: Scopus" |
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