Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy Journal Article

   

Authors:	Aytes, A.; Mitrofanova, A.; Lefebvre, C.; Alvarez, M. J.; Castillo-Martin, M.; Zheng, T.; Eastham, J. A.; Gopalan, A.; Pienta, K. J.; Shen, M. M.; Califano, A.; Abate-Shen, C.
Article Title:	Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy
Abstract:	To identify regulatory drivers of prostate cancer malignancy, we have assembled genome-wide regulatory networks (interactomes) for human and mouse prostate cancer from expression profiles of human tumors and of genetically engineered mouse models, respectively. Cross-species computational analysis of these interactomes has identified FOXM1 and CENPF as synergistic master regulators of prostate cancer malignancy. Experimental validation shows that FOXM1 and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy. Furthermore, co-expression of FOXM1 and CENPF is a robust prognostic indicator of poor survival and metastasis. Thus, genome-wide cross-species interrogation of regulatory networks represents a valuable strategy to identify causal mechanisms of human cancer. © 2014 Elsevier Inc.
Journal Title:	Cancer Cell
Volume:	25
Issue:	5
ISSN:	1535-6108
Publisher:	Cell Press
Date Published:	2014-05-12
Start Page:	638
End Page:	651
Language:	English
DOI:	10.1016/j.ccr.2014.03.017
PROVIDER:	scopus
PUBMED:	24823640
PMCID:	PMC4051317
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84900328733&partnerID=40&md5=229c57630a0118956d5363d915c6d3b0
Notes:	Cancer Cell -- Export Date: 2 June 2014 -- CODEN: CCAEC -- Source: Scopus

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