Genomic approaches to zebrafish cancer Journal Article


Authors: White, R. M.; Langenau, D. M.
Article Title: Genomic approaches to zebrafish cancer
Abstract: The zebrafish has emerged as an important model for studying cancer biology. Identification of DNA, RNA and chromatin abnormalities can give profound insight into the mechanisms of tumorigenesis and the there are many techniques for analyzing the genomes of these tumors. Here, I present an overview of the available technologies for analyzing tumor genomes in the zebrafish, including array based methods as well as next-generation sequencing technologies. I also discuss the ways in which zebrafish tumor genomes can be compared to human genomes using cross-species oncogenomics, which act to filter genomic noise and ultimately uncover central drivers of malignancy. Finally, I discuss downstream analytic tools, including network analysis, that can help to organize the alterations into coherent biological frameworks that can then be investigated further. © Springer International Publishing Switzerland 2016.
Keywords: zebrafish; rna-seq; next-generation sequencing; cancer; oncogenomics
Journal Title: Advances in Experimental Medicine and Biology
Volume: 916
ISSN: 0065-2598
Publisher: Springer  
Date Published: 2016-01-01
Start Page: 125
End Page: 145
Language: English
DOI: 10.1007/978-3-319-30654-4_6
PROVIDER: scopus
PUBMED: 27165352
PMCID: PMC5568896
DOI/URL:
Notes: Book Chapter in "Cancer and Zebrafish: Mechanisms, Techniques, and Models" (ISBN: 978-3-319-30652-0) -- Export Date: 2 August 2016 -- Source: Scopus
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  1. Richard Mark White
    29 White