Mouse models of brain tumors and their applications in preclinical trials Journal Article
| Authors: | Fomchenko, E. I.; Holland, E. C. |
| Article Title: | Mouse models of brain tumors and their applications in preclinical trials |
| Abstract: | Primary brain tumors, including gliomas and medulloblastomas, often represent the most devastating and difficult-to-treat tumors, and are thought to arise from glial cells and/or their precursors or the external granule cell layer, respectively. The majority of genetic alterations characteristic of the human brain tumors are thought to occur in genes encoding proteins involved in signal transduction or cell cycle regulation. Accurate recapitulation of these genetic alterations using genetically engineered mouse models allows for in vivo modeling of brain tumors with similar histopathology, etiology, and biology. These mouse models, in turn, increase our understanding of brain tumor initiation, formation, progression, and metastasis, providing an experimental system to discover novel therapeutic targets and test various therapeutic agents. © 2006 American Association for Cancer Research. |
| Keywords: | signal transduction; cancer chemotherapy; cancer surgery; unclassified drug; gene mutation; somatic mutation; clinical trial; histopathology; review; sorafenib; cisplatin; erlotinib; drug potentiation; nonhuman; unspecified side effect; antineoplastic agents; cancer radiotherapy; temozolomide; brain tumor; glioma; brain neoplasms; magnetic resonance imaging; cell proliferation; animals; mice; imatinib; cancer susceptibility; drug inhibition; unindexed drug; metastasis; models, biological; etoposide; cyclophosphamide; vincristine; tumor xenograft; drug evaluation, preclinical; drug design; cancer model; carmustine; lomustine; procarbazine; cell type; mice, transgenic; temsirolimus; drug mechanism; genetic engineering; cell culture; granule cell; medulloblastoma; gefitinib; protein farnesyltransferase inhibitor; tipifarnib; 2,4 dimethyl 5 (2 oxo 1h indol 3 ylmethylene) 3 pyrrolepropionic acid; vatalanib; glia cell; chromosome translocation; tumor growth; disease models, animal; cell cycle regulation; everolimus; rapamycin; lapatinib; perifosine; enzastaurin; 2 morpholino 8 phenylchromone; wortmannin; epidermal growth factor receptor kinase inhibitor; protein kinase c inhibitor; 2 (2 chloro 4 iodoanilino) n cyclopropylmethoxy 3,4 difluorobenzamide; 6 [4 (4 ethyl 1 piperazinylmethyl)phenyl] 4 (alpha methylbenzylamino) 7h pyrrolo[2,3 d]pyrimidine; cognitive development; 3 benzyl 7 cyano 2,3,4,5 tetrahydro 1 (1h imidazol 4 ylmethyl) 4 (2 thienylsulfonyl) 1h 1,4 benzodiazepine; l 778123; lonafarnib; 17 hydroxywortmannin; pwt 458; physical development |
| Journal Title: | Clinical Cancer Research |
| Volume: | 12 |
| Issue: | 18 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-09-15 |
| Start Page: | 5288 |
| End Page: | 5297 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-06-0438 |
| PUBMED: | 17000661 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 75" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus" |
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