Bi-directional protein transport between the ER and Golgi Journal Article
| Authors: | Lee, M. C. S.; Miller, E. A.; Goldberg, J.; Orci, L.; Schekman, R. |
| Article Title: | Bi-directional protein transport between the ER and Golgi |
| Abstract: | The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between these compartments, reflecting the transport of newly synthesized proteins out of the ER and the retrieval of escaped ER residents and vesicle machinery. Anterograde and retrograde transport is mediated by distinct sets of cytosolic coat proteins, the COPII and COPI coats, respectively, which act on the membrane to capture cargo proteins into nascent vesicles. We review the mechanisms that govern coat recruitment to the membrane, cargo capture into a transport vesicle, and accurate delivery to the target organelle. |
| Keywords: | review; nonhuman; animals; cell compartmentalization; endoplasmic reticulum; protein synthesis; protein transport; protein secretion; cell fusion; golgi complex; membrane vesicle; coated vesicle; snare protein; transport vesicle; golgi apparatus; transport vesicles; vesicle transport; coat protein; active transport; copii; copi; cargo selection; human; priority journal; coat proteins |
| Journal Title: | Annual Review of Cell and Developmental Biology |
| Volume: | 20 |
| ISSN: | 1081-0706 |
| Publisher: | Annual Reviews |
| Date Published: | 2004-01-01 |
| Start Page: | 87 |
| End Page: | 123 |
| Language: | English |
| DOI: | 10.1146/annurev.cellbio.20.010403.105307 |
| PROVIDER: | scopus |
| PUBMED: | 15473836 |
| DOI/URL: | |
| Notes: | Annu. Rev. Cell Dev. Biol. -- Cited By (since 1996):444 -- Export Date: 16 June 2014 -- CODEN: ARDBF -- Source: Scopus |
