Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex Journal Article


Authors: Nickel, W.; Brügger, B.; Wieland, F. T.
Article Title: Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex
Abstract: Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles.
Keywords: carrier protein; review; proteins; metabolism; biological model; models, biological; protein; gtp-binding proteins; membrane proteins; physiology; carrier proteins; membrane protein; phosphoproteins; cholesterol; saccharomyces cerevisiae proteins; saccharomyces cerevisiae protein; eukaryotic cell; guanosine triphosphate; guanine nucleotide binding protein; ultrastructure; phosphoprotein; biological transport; fungal protein; secretion; membrane lipid; macromolecule; macromolecular substances; golgi complex; nuclear pore complex proteins; sphingomyelin; fungal proteins; vesicular transport proteins; membrane lipids; transport at the cellular level; monomeric guanine nucleotide binding protein; monomeric gtp-binding proteins; vesicular transport protein; coatomer protein; coated vesicle; nucleoporin; eukaryotic cells; coated vesicles; golgi apparatus; sphingomyelins; rough endoplasmic reticulum; endoplasmic reticulum, rough; copi- and copii-coated vesicles; early secretory pathway; vesicular traffic; sar1 protein, s cerevisiae; sec13 protein, s cerevisiae; sec23 protein, s cerevisiae; sec31 protein, s cerevisiae
Journal Title: Seminars in Cell and Developmental Biology
Volume: 9
Issue: 5
ISSN: 1084-9521
Publisher: Elsevier Inc.  
Date Published: 1998-10-01
Start Page: 493
End Page: 501
Language: English
PUBMED: 9835636
PROVIDER: scopus
DOI: 10.1006/scdb.1998.0256
DOI/URL:
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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  1. Hans-Walter Karl Nickel
    8 Nickel