Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex Journal Article
| Authors: | Nickel, W.; Brügger, B.; Wieland, F. T. |
| Article Title: | Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex |
| Abstract: | Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles. |
| Keywords: | carrier protein; review; proteins; metabolism; biological model; models, biological; protein; gtp-binding proteins; membrane proteins; physiology; carrier proteins; membrane protein; phosphoproteins; cholesterol; saccharomyces cerevisiae proteins; saccharomyces cerevisiae protein; eukaryotic cell; guanosine triphosphate; guanine nucleotide binding protein; ultrastructure; phosphoprotein; biological transport; fungal protein; secretion; membrane lipid; macromolecule; macromolecular substances; golgi complex; nuclear pore complex proteins; sphingomyelin; fungal proteins; vesicular transport proteins; membrane lipids; transport at the cellular level; monomeric guanine nucleotide binding protein; monomeric gtp-binding proteins; vesicular transport protein; coatomer protein; coated vesicle; nucleoporin; eukaryotic cells; coated vesicles; golgi apparatus; sphingomyelins; rough endoplasmic reticulum; endoplasmic reticulum, rough; copi- and copii-coated vesicles; early secretory pathway; vesicular traffic; sar1 protein, s cerevisiae; sec13 protein, s cerevisiae; sec23 protein, s cerevisiae; sec31 protein, s cerevisiae |
| Journal Title: | Seminars in Cell and Developmental Biology |
| Volume: | 9 |
| Issue: | 5 |
| ISSN: | 1084-9521 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-10-01 |
| Start Page: | 493 |
| End Page: | 501 |
| Language: | English |
| PUBMED: | 9835636 |
| PROVIDER: | scopus |
| DOI: | 10.1006/scdb.1998.0256 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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