Exiting the endoplasmic reticulum Journal Article

  


Authors: Mancias, J. D.; Goldberg, J.
Article Title: Exiting the endoplasmic reticulum
Abstract: Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the initial step in protein secretion. COPII-coated vesicles mediate the export of newly synthesized proteins from the ER, and this transport step is coupled with COPI-mediated retrograde traffic to form a transport circuit that supports the compositional asymmetry of the ER-Golgi system. Biochemical and structural studies have advanced our understanding of the mechanisms that control vesicle formation and cargo-protein capture. Recent work has highlighted the function of transitional ER regions in specifying the location of COPII budding. Copyright © Blackwell Munksgaard 2005.
Keywords: signal transduction; carrier protein; review; nonhuman; protein function; protein localization; animals; cell function; cell structure; protein assembly; protein protein interaction; intracellular transport; enzyme activity; endoplasmic reticulum; protein synthesis; membrane protein; cell membrane; protein transport; protein secretion; arf protein; protein structure; guanosine triphosphate; guanine nucleotide binding protein; protein hydrolysis; golgi complex; transport kinetics; guanosine diphosphate; guanosine triphosphatase; coat protein complex i; coat protein complex ii; coated vesicle; cop-coated vesicles; snare protein; transport vesicle; glycosylated protein; copii; sar1; sec12; snare
Journal Title: Traffic
Volume: 6
Issue: 4
ISSN: 1398-9219
Publisher: Wiley Blackwell  
Date Published: 2005-04-01
Start Page: 278
End Page: 285
Language: English
DOI: 10.1111/j.1600-0854.2005.00279.x
PUBMED: 15752134
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-15844406577&partnerID=40&md5=3b710edbed9785c9a961be44dd071773
Notes: --- - "Cited By (since 1996): 35" - "Export Date: 24 October 2012" - "CODEN: TRAFF" - "Source: Scopus"
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MSK Authors
  1. Jonathan D Goldberg
    22 Goldberg
  2. Joseph Mancias
    5 Mancias
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