COPI-mediated protein and lipid sorting in the early secretory pathway Journal Article
| Authors: | Nickel, W.; Brügger, B. |
| Article Title: | COPI-mediated protein and lipid sorting in the early secretory pathway |
| Abstract: | The major function of the secretory pathway of eukaryotes is to maintain the compartmental organization of the endomembrane system and organelle-associated functions by proper distribution of newly synthesized molecules. Protein and lipid transport is mediated by vesicular intermediates that connect the various organelles throughout this pathway. This principle enables the eukaryotic cell to actively sort proteins and lipids at every level of this route, in both the anterograde and the retrograde direction. Here, we discuss the molecular mechanisms of nonclathrin(COPI and COPII)-coated-vesicle biogenesis and how transport vesicle formation is linked to protein and lipid sorting in the early secretory pathway. |
| Keywords: | cell organelle; secretory pathway; coated vesicles; copi; retrograde transport; protein sorting; anterograde transport; lipid sorting |
| Journal Title: | Protoplasma |
| Volume: | 207 |
| Issue: | 3-4 |
| ISSN: | 0033-183X |
| Publisher: | Springer Wien |
| Date Published: | 1999-09-01 |
| Start Page: | 115 |
| End Page: | 124 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1007/BF01282990 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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