COPI-mediated protein and lipid sorting in the early secretory pathway Journal Article


Authors: Nickel, W.; Br├╝gger, B.
Article Title: COPI-mediated protein and lipid sorting in the early secretory pathway
Abstract: The major function of the secretory pathway of eukaryotes is to maintain the compartmental organization of the endomembrane system and organelle-associated functions by proper distribution of newly synthesized molecules. Protein and lipid transport is mediated by vesicular intermediates that connect the various organelles throughout this pathway. This principle enables the eukaryotic cell to actively sort proteins and lipids at every level of this route, in both the anterograde and the retrograde direction. Here, we discuss the molecular mechanisms of nonclathrin(COPI and COPII)-coated-vesicle biogenesis and how transport vesicle formation is linked to protein and lipid sorting in the early secretory pathway.
Keywords: cell organelle; secretory pathway; coated vesicles; copi; retrograde transport; protein sorting; anterograde transport; lipid sorting
Journal Title: Protoplasma
Volume: 207
Issue: 3-4
ISSN: 0033-183X
Publisher: Springer Wien  
Date Published: 1999-09-01
Start Page: 115
End Page: 124
Language: English
PROVIDER: scopus
DOI: 10.1007/BF01282990
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Hans-Walter Karl Nickel
    8 Nickel