The role of radiation therapy in the treatment of medullary thyroid cancer Journal Article
| Authors: | Terezakis, S. A.; Lee, N. Y. |
| Article Title: | The role of radiation therapy in the treatment of medullary thyroid cancer |
| Abstract: | Medullary thyroid cancer (MTC) is a neuroendocrine tumor derived from parafollicular or C cells of the thyroid gland. Surgical resection is the mainstay of treatment for MTC. External-beam radiation treatment (EBRT) has traditionally played a limited role in the management of MTC. Despite aggressive surgery, patients at high risk for local recurrence may benefit from adjuvant EBRT. With improvements in radiation technique, adequate dose can be effectively delivered to the region at risk while minimizing dose to surrounding critical structures. Although the role of EBRT in the management of these tumors has thus far been poorly defined, EBRT should be considered as a treatment option for patients with locally advanced MTC to optimize locoregional control. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | cancer survival; cancer surgery; gene mutation; overall survival; intensity modulated radiation therapy; laryngectomy; cisplatin; doxorubicin; fluorouracil; treatment planning; bone metastasis; cancer radiotherapy; disease free survival; radiation dose; radiotherapy, adjuvant; lymph node metastasis; neurofibromatosis; proto oncogene; tumor volume; radiotherapy dosage; radiotherapy; carcinoembryonic antigen; tumor differentiation; calcitonin; radiation injury; protein tyrosine kinase inhibitor; dysphagia; radioactive iodine; minimal residual disease; imrt; radiotherapy, intensity-modulated; dosimetry; micrometastasis; hyperparathyroidism; cancer relapse; thyroid cancer; thyroid neoplasms; octreotide; external beam radiotherapy; codon; pheochromocytoma; genetic screening; protein ret; carcinoma, medullary; hoarseness; external-beam radiation; thyroid medullary carcinoma; radiotherapy, computer-assisted; medullary thyroid cancer; cricoid; parathyroidectomy; calcitonin blood level; recurrent laryngeal nerve palsy; sipple syndrome; stridor; thyroid parafollicular cell |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2010-05-01 |
| Start Page: | 532 |
| End Page: | 541 |
| Language: | English |
| PUBMED: | 20495083 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
