Outcomes of surgery and postoperative radiation therapy in managing medullary thyroid carcinoma Journal Article
| Authors: | Groen, A. H.; Beckham, T. H.; Links, T. P.; Goldman, D. A.; Sherman, E. J.; Tuttle, M. M.; Bijl, H. P.; Wong, R. J.; Plukker, J. T. M.; Lee, N. Y.; other Group/Consortium Members |
| Contributors: | Riaz, N.; Tsai, C. J.; Yu, Y.; Zhang, Z.; Shaha, A. |
| Article Title: | Outcomes of surgery and postoperative radiation therapy in managing medullary thyroid carcinoma |
| Abstract: | Background and Objectives: We evaluated the outcomes of surgery with or without postoperative radiation therapy (PORT) in the management of medullary thyroid carcinoma (MTC). Methods: From two tertiary cancer centers, 297 consecutive patients with MTC treated with PORT (n = 46) between 1990 and 2016 or surgery alone (n = 251) between 2000 and 2016 were reviewed. Results: Ten-year cumulative incidences of locoregional and distant failure were 30.2% and 24.9% in the surgery cohort, and 16.9% and 55.2% in the PORT cohort. In the surgery alone cohort, T4 disease, extrathyroidal extension, N1 disease, extranodal extension (ENE), and residual disease after surgery were associated with local failure. The PORT cohort had significantly higher proportions of patients with T4 disease, N1 disease, ENE, and residual disease. Conclusions: High-risk clinical features can help identify patients with MTC at high-risk for local failure after surgery alone. Patients with high-risk clinical features had effective locoregional control after PORT. © 2019 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; child; aged; cancer surgery; major clinical study; cancer patient; cancer radiotherapy; postoperative care; outcome assessment; follow up; cancer incidence; cohort analysis; retrospective study; cancer center; minimal residual disease; head and neck cancer; postoperative radiotherapy; thyroid medullary carcinoma; thyroid malignancy; medullary thyroid carcinoma; human; male; female; priority journal; article; tertiary care center |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 121 |
| Issue: | 2 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-02-01 |
| Start Page: | 234 |
| End Page: | 243 |
| Language: | English |
| DOI: | 10.1002/jso.25761 |
| PUBMED: | 31733124 |
| PROVIDER: | scopus |
| PMCID: | PMC8011335 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2020 -- Source: Scopus |
