Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation Journal Article
| Authors: | Ali, S.; Palmer, F. L.; Katabi, N.; Lee, N.; Shah, J. P.; Patel, S. G.; Ganly, I. |
| Article Title: | Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation |
| Abstract: | Objectives: To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure. Study Design: Single-institution retrospective cohort study. Methods: Eighty-seven patients who had surgery for ACC between 1985 and 2009 were identified. Patient, tumor, and treatment characteristics were recorded. Local recurrence-free survival (LRFS) was recorded by the Kaplan-Meier method. Predictors of local control were identified. Results: The median age was 54 years. Seventy-two (83%) patients had perineural invasion, 61 (70%) had close/positive margins, and 58 (67%) had pT 1T2. Fifty-nine (68%) patients had postoperative radiation therapy (PORT). With a median follow-up of 85 months, the 10-year LRFS was 78.7%. There were 14 local recurrences. On multivariable analysis, pathological tumor (T)3T4 stage and no PORT were independent predictors for local failure. Patients with no PORT had a 13-fold increased risk of local failure compared to patients treated with PORT (P = 0.003) after adjusting for stage. Conclusion: After adjusting for T stage, patients who do not get PORT are more likely to have local recurrence. Level of Evidence: 4. Laryngoscope, 127:2265–2269, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc. |
| Keywords: | radiotherapy; salivary gland; adenoid cystic carcinoma; local recurrence |
| Journal Title: | Laryngoscope |
| Volume: | 127 |
| Issue: | 10 |
| ISSN: | 0023-852X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2017-10-01 |
| Start Page: | 2265 |
| End Page: | 2269 |
| Language: | English |
| DOI: | 10.1002/lary.26565 |
| PROVIDER: | scopus |
| PUBMED: | 28322454 |
| PMCID: | PMC5661868 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 October 2017 -- Source: Scopus |
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