A risk-adapted approach to the use of radioactive iodine and external beam radiation in the treatment of well-differentiated thyroid cancer Journal Article
| Authors: | Tuttle, R. M.; Rondeau, G.; Lee, N. Y. |
| Article Title: | A risk-adapted approach to the use of radioactive iodine and external beam radiation in the treatment of well-differentiated thyroid cancer |
| Abstract: | Background: Both radioactive iodine (RAI) and external beam radiation therapy (EBRT) offer mportant clinical benefits in properly selected patients with differentiated thyroid cancer. With the increased emphasis on a risk-adapted model for the management of thyroid cancer, it is important to identify which patients are most likely to benefit from radiation therapies given in the adjuvant setting and as treatment of gross residual disease. Methods: This review compares the authors' current management practices with the recommendations of published guidelines from both the National Comprehensive Cancer Network and the American Thyroid Association. Results: Because of the lack of prospective randomized studies on either RAI or EBRT in differentiated thyroid cancer, recommendations must be based on retrospective cohort studies that vary in selection criteria, histologies, sample size, inclusion criteria, and follow-up. Conclusions: RAI has an important adjuvant therapy and treatment function in properly selected patients. Likewise, EBRT is associated with increased locoregional control and palliative therapeutic effects in high-risk patients. |
| Keywords: | cancer survival; cancer recurrence; intensity modulated radiation therapy; dose response; drug safety; side effect; bone metastasis; cancer adjuvant therapy; cancer radiotherapy; radiation dose; lymph node metastasis; lymph node dissection; clinical practice; cancer palliative therapy; treatment indication; metastasis; tumor differentiation; cancer mortality; distant metastasis; high risk patient; risk assessment; lung metastasis; radioactive iodine; brain metastasis; thrombocyte count; xerostomia; recurrent disease; thyroidectomy; salivary gland disease; thyroid cancer; clinical effectiveness; external beam radiotherapy; leukocyte count; cancer control; radiofrequency ablation; esophagus stricture; local metastasis; regional metastasis; fluorodeoxyglucose; repeated drug dose; pharyngitis; skin fibrosis; metastasis resection; saliva; trachea stenosis |
| Journal Title: | Cancer Control |
| Volume: | 18 |
| Issue: | 2 |
| ISSN: | 1073-2748 |
| Publisher: | H. Lee Moffitt Cancer Center & Research Institute |
| Date Published: | 2011-04-01 |
| Start Page: | 89 |
| End Page: | 95 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 21451451 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: CACOF" - "Source: Scopus" |
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