The role of external beam radiation and targeted therapy in thyroid cancer Journal Article
| Authors: | Brierley, J.; Sherman, E. |
| Article Title: | The role of external beam radiation and targeted therapy in thyroid cancer |
| Abstract: | The initial management of thyroid cancer is usually surgery, followed by radioactive iodine in differentiated thyroid cancer. The role of external beam radiotherapy for gross residual or unresected disease is discussed. For both differentiated thyroid cancer and medullary thyroid cancer, the role of external beam radiotherapy after resection of gross disease when there is a high risk of local regional failure is reviewed. In anaplastic thyroid cancers, although most patients present with unresectable disease and radiotherapy is the mainstay of treatment, the benefits of the addition of chemotherapy to radiation therapy will be discussed. Patient selection, radiation volumes, and radiation doses will be discussed. As in other tumor sites, external beam radiation has an import role in the palliative management of patient with metastatic thyroid cancer of all histologies, especially of metastases to bone but also brain and lung, but this role is not described in the review. © 2012 Elsevier Inc. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein kinase b; cancer chemotherapy; cancer survival; cancer surgery; treatment failure; overall survival; review; cancer recurrence; intensity modulated radiation therapy; sorafenib; doxorubicin; patient selection; treatment planning; paclitaxel; cancer radiotherapy; radiation dose; combined modality therapy; positron emission tomography; antineoplastic agent; imatinib; melanoma; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; esophagitis; mucosa inflammation; radiotherapy dosage; angiogenesis; phosphatidylinositol 3 kinase; docetaxel; dysphagia; radiotherapy, intensity-modulated; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; combretastatin a4 phosphate; pazopanib; radiation injuries; thyroid cancer; thyroid neoplasms; external beam radiotherapy; axitinib; esophagus stricture; b raf kinase; chemoradiotherapy; carcinoma, medullary; thyroid medullary carcinoma; differentiated thyroid cancer; pharyngitis; molecular targeted therapy; anaplastic thyroid cancer; vemurafenib; larynx edema; dabrafenib |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 22 |
| Issue: | 3 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-07-01 |
| Start Page: | 254 |
| End Page: | 262 |
| Language: | English |
| DOI: | 10.1016/j.semradonc.2012.03.010 |
| PROVIDER: | scopus |
| PUBMED: | 22687950 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: SRONE" - "Source: Scopus" |
