Clonal origins of neocortical interneurons Journal Article
| Authors: | Sultan, K. T.; Shi, W.; Shi, S. H. |
| Article Title: | Clonal origins of neocortical interneurons |
| Abstract: | Once referred to as 'short-axon' neurons by Cajal, GABA (gamma-amino butyric acid)-ergic interneurons are essential components of the neocortex. They are distributed throughout the cortical laminae and are responsible for shaping circuit output through a rich array of inhibitory mechanisms. Numerous fate-mapping and transplantation studies have examined the embryonic origins of the diversity of interneurons that are defined along various parameters such as morphology, neurochemical marker expression and physiological properties, and have been extensively reviewed elsewhere. Here, we focus on discussing two recent studies that have, for the first time, examined the production and organization of neocortical interneurons originated from individual progenitors, that is, with clonal resolution, and provided important new insights into the cellular processes underlying the development of inhibitory interneurons in the neocortex. © 2014 Elsevier Ltd. |
| Keywords: | controlled study; protein expression; review; nonhuman; cell proliferation; cell function; cell maturation; cell fate; stem cell; gabaergic system; interneuron; cellular distribution; neocortex; brain mapping; somatostatin; perinatal period; coiled body; oligodendroglia; 4 aminobutyric acid; parvalbumin; preoptic area; median eminence; priority journal; cholinergic system |
| Journal Title: | Current Opinion in Neurobiology |
| Volume: | 26C |
| ISSN: | 0959-4388 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-06-01 |
| Start Page: | 125 |
| End Page: | 131 |
| Language: | English |
| DOI: | 10.1016/j.conb.2014.01.010 |
| PROVIDER: | scopus |
| PUBMED: | 24531366 |
| PMCID: | PMC4024342 |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- CODEN: COPUE -- Source: Scopus |
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