Challenges after curative treatment for childhood cancer and long-term follow up of survivors Journal Article
| Authors: | Oeffinger, K. C.; Nathan, P. C.; Kremer, L. C. M. |
| Article Title: | Challenges after curative treatment for childhood cancer and long-term follow up of survivors |
| Abstract: | Childhood cancer survivors are at increased risk of serious morbidity, premature mortality, and diminished health status. Proactive and anticipatory risk-based health care of survivors and healthy lifestyles can reduce these risks. In this article, the authors first briefly discuss four common problems of survivors: neurocognitive dysfunction, cardiovascular disease, infertility and gonadal dysfunction, and psychosocial problems. Second, the authors discuss the concept of risk-based care, promote the use of recently developed evidence-based guidelines, describe current care in the United States, Canada, and the Netherlands, and articulate a model for shared survivor care that aims to optimize life long health of survivors and improve two-way communication between the cancer center and the primary care physician. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | osteosarcoma; cancer chemotherapy; child; treatment outcome; busulfan; clinical trial; review; cisplatin; dose response; drug dose reduction; heart left ventricle failure; side effect; treatment duration; cancer radiotherapy; radiation dose; cytarabine; methotrexate; drug megadose; follow up; follow-up studies; antineoplastic agent; neoplasms; multiple cycle treatment; evidence based practice; alkylating agent; cyclophosphamide; melphalan; vincristine; stem cell transplantation; radiation injury; chlormethine; ifosfamide; procarbazine; acute lymphoblastic leukemia; central nervous system tumor; childhood cancer; gonad dysfunction; high risk patient; hodgkin disease; infertility; ovary insufficiency; survivor; late effects; age; cancer survivor; risk assessment; survivors; ewing sarcoma; cryopreservation; myeloablative conditioning; nonhodgkin lymphoma; doctor patient relation; cardiovascular disease; heart failure; heart infarction; cardiovascular diseases; cardiotoxicity; long term care; neuropsychological test; corticosteroid derivative; posttraumatic stress disorder; interpersonal communication; cognitive defect; sex difference; gonadorelin derivative; testosterone blood level; anthracycline derivative; lifestyle modification; drug dose increase; dipeptidyl carboxypeptidase inhibitor; coronary artery disease; primary medical care; low energy radiation; androgen deficiency; cooperation; psychotherapy; psychosocial disorder; acute disease; cardiomyopathy; semen analysis; male infertility; oligospermia; academic achievement; azoospermia; infertility therapy; spermatogenesis; child health care; enalapril; carotid artery disease; early menopause; mantle field radiotherapy; ovarian reserve; pregnancy complication |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 1 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-02-01 |
| Start Page: | 129 |
| End Page: | 149 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2009.11.013 |
| PUBMED: | 20113899 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: HCNAE" - "Source: Scopus" |
