Ulcer, gastric surgery and pancreatic cancer risk: An analysis from the international pancreatic cancer case-control consortium (PanC4) Journal Article
| Authors: | Bosetti, C.; Lucenteforte, E.; Bracci, P. M.; Negri, E.; Neale, R. E.; Risch, H. A.; Olson, S. H.; Gallinger, S.; Miller, A. B.; Bueno-de-Mesquita, H. B.; Talamini, R.; Polesel, J.; Ghadirian, P.; Baghurst, P. A.; Zatonski, W.; Fontham, E.; Holly, E. A.; Gao, Y. T.; Yu, H.; Kurtz, R. C.; Cotterchio, M.; Maisonneuve, P.; Zeegers, M. P.; Duell, E. J.; Boffetta, P.; La Vecchia, C. |
| Article Title: | Ulcer, gastric surgery and pancreatic cancer risk: An analysis from the international pancreatic cancer case-control consortium (PanC4) |
| Abstract: | Background: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. Methods: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. Results: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. Conclusions: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance. © The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology All rights reserved. |
| Keywords: | gastrectomy; pancreatic cancer; pooled analysis; peptic ulcer; case-control study; anti-ulcer drugs |
| Journal Title: | Annals of Oncology |
| Volume: | 24 |
| Issue: | 11 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2013-11-01 |
| Start Page: | 2903 |
| End Page: | 2910 |
| Language: | English |
| DOI: | 10.1093/annonc/mdt336 |
| PROVIDER: | scopus |
| PMCID: | PMC3811904 |
| PUBMED: | 23970016 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 December 2013" - "Art. No.: mdt336" - "CODEN: ANONE" - "Source: Scopus" |
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