Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4) Journal Article
| Authors: | Bertuccio, P.; La Vecchia, C.; Silverman, D. T.; Petersen, G. M.; Bracci, P. M.; Negri, E.; Li, D.; Risch, H. A.; Olson, S. H.; Gallinger, S.; Miller, A. B.; Bueno-de-Mesquita, H. B.; Talamini, R.; Polesel, J.; Ghadirian, P.; Baghurst, P. A.; Zatonski, W.; Fontham, E. T.; Bamlet, W. R.; Holly, E. A.; Lucenteforte, E.; Hassan, M.; Yu, H.; Kurtz, R. C.; Cotterchio, M.; Su, J.; Maisonneuve, P.; Duell, E. J.; Bosetti, C.; Boffetta, P. |
| Article Title: | Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4) |
| Abstract: | Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; middle aged; major clinical study; case-control studies; cigarette smoking; cancer risk; pancreas cancer; pancreatic neoplasms; demography; smoking; risk assessment; risk; body mass; anthropometry; sex difference; pancreatic cancer; tobacco; alcohol consumption; race difference; ethnicity; environmental exposure; pooled analysis; cigar; pipe; smokeless tobacco; tobacco use disorder; tobacco, smokeless |
| Journal Title: | Annals of Oncology |
| Volume: | 22 |
| Issue: | 6 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2011-06-01 |
| Start Page: | 1420 |
| End Page: | 1426 |
| Language: | English |
| DOI: | 10.1093/annonc/mdq613 |
| PROVIDER: | scopus |
| PMCID: | PMC3139985 |
| PUBMED: | 21245160 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: ANONE" - "Source: Scopus" |
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