Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers Journal Article
| Authors: | Oh, S. S.; Chang, S. C.; Cai, L.; Cordon-Cardo, C.; Ding, B. G.; Greenland, S.; He, N.; Jiang, Q.; Kheifets, L.; Le, A.; Lee, Y. C. A.; Liu, S.; Lu, M. L.; Mao, J. T.; Morgenstern, H.; Mu, L. N.; Pantuck, A.; Papp, J. C.; Park, S. L.; Rao, J. Y.; Reuter, V. E.; Tashkin, D. P.; Wang, H.; You, N. C. Y.; Yu, S. Z.; Zhao, J. K.; Belldegrun, A.; Zhang, Z. F. |
| Article Title: | Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers |
| Abstract: | Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation-related genes with tobacco-related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case-control studies from: Los Angeles (population-based; 611 lung and 553 upper aero-digestive tract cancer cases and 1,040 controls), Taixing, China (population-based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan-Kettering Cancer Center (hospital-based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking-related cancer (CC vs. CT+TT aOR: 0.36, 95% CI: 0.17-0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking-related cancers among never smokers. © 2010 UICC. |
| Keywords: | adult; controlled study; middle aged; major clinical study; single nucleotide polymorphism; case control study; genetics; case-control studies; polymorphism, single nucleotide; laryngeal neoplasms; united states; neoplasm; neoplasms; cancer susceptibility; bayesian learning; lung neoplasms; interleukin 10; interleukin 1beta; inflammation; genetic association; genetic variability; lung cancer; smoking; bladder cancer; age; carcinogenesis; single nucleotide polymorphisms; lung tumor; tnf; gamma interferon; education; epigenetics; oropharynx cancer; stomach cancer; liver cancer; kidney cancer; gender; esophagus cancer; larynx cancer; ethnicity; oropharyngeal neoplasms; tumor necrosis factor; china; larynx tumor; oropharynx tumor; il10; tobacco-related cancer; gamma interferon receptor 1 |
| Journal Title: | International Journal of Cancer |
| Volume: | 127 |
| Issue: | 9 |
| ISSN: | 0020-7136 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2010-11-01 |
| Start Page: | 2169 |
| End Page: | 2182 |
| Language: | English |
| DOI: | 10.1002/ijc.25214 |
| PUBMED: | 20112337 |
| PROVIDER: | scopus |
| PMCID: | PMC2932751 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: IJCNA" - "Source: Scopus" |
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