Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites Journal Article

   


Authors: Park, S. L.; Chang, S. C.; Cai, L.; Cordon-Cardo, C.; Ding, B. G.; Greenland, S.; Hussain, S. K.; Jiang, Q.; Liu, S.; Lu, M. L.; Mao, J. T.; Morgenstern, H.; Mu, L. N.; Ng, L. J.; Pantuck, A.; Rao, J.; Reuter, V. E.; Tashkin, D. P.; You, N. C. Y.; Yu, C. Q.; Yu, S. Z.; Zhao, J. K.; Belldegrun, A.; Zhang, Z. F.
Article Title: Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites
Abstract: Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined "regions" within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (OR adj), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (ORadj, 1.80; 95% CI, 1.30-2.49) and larynx (ORadj, 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among eversmokers (OR adj, 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (ORadj, 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers. Copyright © 2008 American Association for Cancer Research.
Keywords: adolescent; adult; controlled study; human tissue; aged; middle aged; single nucleotide polymorphism; case-control studies; polymorphism, single nucleotide; cancer localization; liver neoplasms; neoplasms; genetic predisposition to disease; lung neoplasms; gene locus; genetic association; genetic variability; genotype; alleles; genetic variation; lung cancer; smoking; chromosomes, human, pair 8; bladder cancer; urinary bladder neoplasms; risk; carcinogenesis; oropharynx cancer; stomach cancer; chi-square distribution; liver cancer; kidney cancer; esophagus cancer; nasopharynx cancer; larynx cancer; chromosome 8q; otorhinolaryngologic neoplasms
Journal Title: Cancer Epidemiology Biomarkers and Prevention
Volume: 17
Issue: 11
ISSN: 1055-9965
Publisher: American Association for Cancer Research  
Date Published: 2008-11-01
Start Page: 3193
End Page: 3202
Language: English
DOI: 10.1158/1055-9965.epi-08-0523
PUBMED: 18990762
PROVIDER: scopus
PMCID: PMC2664075
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-55849117363&partnerID=40&md5=0c37617331247916e951de0d0d8fd77b
Notes: --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: CEBPE" - "Source: Scopus"
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Minglan Lu
    23 Lu
  3. Victor Reuter
    1228 Reuter
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