The association between peptic ulcer disease and gastric cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium Journal Article


Authors: Paragomi, P.; Dabo, B.; Pelucchi, C.; Bonzi, R.; Bako, A. T.; Sanusi, N. M.; Nguyen, Q. H.; Zhang, Z. F.; Palli, D.; Ferraroni, M.; Vu, K. T.; Yu, G. P.; Turati, F.; Zaridze, D.; Maximovitch, D.; Hu, J.; Mu, L.; Boccia, S.; Pastorino, R.; Tsugane, S.; Hidaka, A.; Kurtz, R. C.; Lagiou, A.; Lagiou, P.; Camargo, M. C.; Curado, M. P.; Lunet, N.; Vioque, J.; Boffetta, P.; Negri, E.; La Vecchia, C.; Luu, H. N.
Article Title: The association between peptic ulcer disease and gastric cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
Abstract: Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk. © 2022 by the authors.
Keywords: risk factors; gastric cancer; duodenal ulcers (dus); gastric ulcers (gus)
Journal Title: Cancers
Volume: 14
Issue: 19
ISSN: 2072-6694
Publisher: MDPI  
Date Published: 2022-10-01
Start Page: 4905
Language: English
DOI: 10.3390/cancers14194905
PROVIDER: scopus
PMCID: PMC9563899
PUBMED: 36230828
DOI/URL:
Notes: Article -- Export Date: 1 November 2022 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Robert C Kurtz
    196 Kurtz