Pancreatitis and pancreatic cancer risk: A pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4) Journal Article
| Authors: | Duell, E. J.; Lucenteforte, E.; Olson, S. H.; Bracci, P. M.; Li, D.; Risch, H. A.; Silverman, D. T.; Ji, B. T.; Gallinger, S.; Holly, E. A.; Fontham, E. H.; Maisonneuve, P.; Bueno-de-Mesquita, H. B.; Ghadirian, P.; Kurtz, R. C.; Ludwig, E.; Yu, H.; Lowenfels, A. B.; Seminara, D.; Petersen, G. M.; La Vecchia, C.; Boffetta, P. |
| Article Title: | Pancreatitis and pancreatic cancer risk: A pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4) |
| Abstract: | Background: Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. Patients and methods: A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10 947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). Results: The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of ≤2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (<65 years) pancreatic cancer cases showed stronger associations with previous (>2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (≥65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006). Conclusions: Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. |
| Keywords: | case-control studies; risk factors; pancreatitis; pancreatic cancer; pooled analysis |
| Journal Title: | Annals of Oncology |
| Volume: | 23 |
| Issue: | 11 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2012-11-01 |
| Start Page: | 2964 |
| End Page: | 2970 |
| Language: | English |
| DOI: | 10.1093/annonc/mds140 |
| PROVIDER: | scopus |
| PMCID: | PMC3477881 |
| PUBMED: | 22767586 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "Art. No.: mds140" - "CODEN: ANONE" - "Source: Scopus" |
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