Prediction of 2 years-survival in patients with stage I and II non-small cell lung cancer utilizing (18)F-FDG PET/CT SUV quantification Journal Article
| Authors: | Cistaro, A.; Quartuccio, N.; Mojtahedi, A.; Fania, P.; Filosso, P. L.; Campenni, A.; Ficola, U.; Baldari, S. |
| Article Title: | Prediction of 2 years-survival in patients with stage I and II non-small cell lung cancer utilizing (18)F-FDG PET/CT SUV quantification |
| Abstract: | Background. The purpose of the study was to evaluate the correlation between the maximum standardized uptake value (SUVmax), size of primary lung lesion, disease-free survival (DFS) and overall survival (OS) in patients with stage I and II non-small cell lung cancer (NSCLC) in 2 years follow-up. Patients and methods. Forty-nine patients with stage I-II NSCLC were included in this study. Pre-surgical 2-deoxy-2-[18F]fluoro-D-glucose positron-emission tomography (F-18-FDG PET/CT) study was performed for all patients. The relationship between SUVmax, tumour size and clinical outcome was measured. The cut-off value for SUVmax and tumour size with the best prognostic significance, probability of DFS and the correlation between SUVmax and the response to therapy were calculated. Results. There was a statistically significant correlation between SUVmax and DFS (p = 0.029). The optimal cut-offs were 9.00 for SUVmax (p = 0.0013) and 30mm for tumour size (p = 0.0028). Patients with SUVmax > 9 and primary lesion size > 30 mm had an expected 2years-DFS of 37.5%, while this rose to 90% if the tumour was <30 mm and/or SUVmax was <9. Conclusions. In stage I-II, SUVmax and tumour size might be helpful to identify the subgroup of patients with high chance for recurrence. |
| Keywords: | survival; overall survival; fdg-pet; standardized uptake value; positron-emission-tomography; prognostic; value; fluorodeoxyglucose uptake; disease-free; maximum standardized uptake value; scan; 2-deoxy-2-[18f]fluoro-d-glucose positron emission tomography; non-small; cell lung cancer |
| Journal Title: | Radiology and Oncology |
| Volume: | 47 |
| Issue: | 3 |
| ISSN: | 1318-2099 |
| Publisher: | Assoc Radiology & Oncology |
| Date Published: | 2013-01-01 |
| Start Page: | 219 |
| End Page: | 223 |
| Language: | English |
| DOI: | 10.2478/raon-2013-0023 |
| ACCESSION: | WOS:000322968000003 |
| PROVIDER: | wos |
| PMCID: | PMC3794876 |
| PUBMED: | 24133385 |
| Notes: | --- - Article - "Source: Wos" |
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