Prognostic value of preradiotherapy (18)F-FDG PET/CT volumetrics in limited-stage small-cell lung cancer Journal Article


Authors: Ong, L. T.; Dunphy, M.; Foster, A.; Woo, K. M.; Zhang, Z.; Perez, C. A.; Pietanza, C. M.; Rosenzweig, K. E.; Gelblum, D. Y.; Rimner, A.; Wu, A. J.
Article Title: Prognostic value of preradiotherapy (18)F-FDG PET/CT volumetrics in limited-stage small-cell lung cancer
Abstract: There are conflicting data on whether F-18-fludeoxyglucose positron emission tomography (PET)/computed tomography metrics predict outcome in small-cell lung cancer (SCLC). This is the largest cohort of limited-stage SCLC yet analyzed and utilized advanced PET metrics in addition to maximal standardized uptake value. No independently significant correlations with outcome were identified, indicating more definitively that PET is not prognostic in SCLC. Background: Whether F-18-fludeoxyglucose positron emission tomography (PET)/computed tomography (CT) metrics predict outcome in limited-stage (LS) small-cell lung cancer (SCLC) has not been well established; most previous reports have only analyzed maximal standardized uptake values (SUVmax). We investigated multiple pretreatment PET metrics, including SUVmax, mean SUV (SUVmean), total lesion glycolysis, and metabolic tumor volume (MTV) in LS-SCLC patients undergoing chemoradiotherapy (CRT) and correlated them with survival and disease control outcomes. Patients and Methods: All patients received platinum-based chemotherapy and a median radiation dose of 45 Gy. Kaplan-Meier and competing-risks analyses were performed to assess the prognostic value of PET metrics with respect to overall survival (OS), distant failure (DF), disease-free survival (DFS), and locoregional failure (LRF). Univariate and multivariate analyses were performed to account for the effect of other clinical factors on outcomes. Results: A total of 120 patients with LS-SCLC had analyzable pre-CRT PET/CTs. The median follow up was 34 months. Median OS was 26.9 months. OS was 53.2% at 2 years and 33.1% at 5 years. SUVmax, SUVmean, MTV, and total lesion glycolysis of the primary tumor were not significantly associated with OS, LRF, and DFS on univariate analysis. MTV was significantly associated with DF (P = .024) on univariate but not multivariate analysis. Conclusion: This is the largest reported series to date evaluating the prognostic value of baseline PET metrics in LS-SCLC. Neither SUVmax nor other analyzed PET metrics demonstrated significant correlation with OS or LRF. MTV was correlated with DF and DFS, but this association was no longer significant after adjustment for other clinical factors. This analysis suggests that pretreatment PET scans, even with the use of advanced metrics, do not have independent prognostic value for outcomes in LS-SCLC patients after CRT.
Keywords: survival; lung cancer; chemoradiotherapy; overall; advanced pet metrics; mtv
Journal Title: Clinical Lung Cancer
Volume: 17
Issue: 3
ISSN: 1525-7304
Publisher: Elsevier Inc.  
Date Published: 2016-05-01
Start Page: 184
End Page: 188
Language: English
ACCESSION: WOS:000377399300004
DOI: 10.1016/j.cllc.2015.07.004
PROVIDER: wos
PMCID: PMC4740253
PUBMED: 26320828
Notes: Article -- Source: Wos
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MSK Authors
  1. Zhigang Zhang
    258 Zhang
  2. Daphna Y Gelblum
    86 Gelblum
  3. Maria C Pietanza
    120 Pietanza
  4. Mark Phillip Dunphy
    53 Dunphy
  5. Carmen Ana Perez
    17 Perez
  6. Andreas Rimner
    286 Rimner
  7. Abraham Jing-Ching Wu
    225 Wu
  8. Leonard Tsung-Wei Ong
    23 Ong
  9. Amanda Foster
    62 Foster
  10. Kaitlin Marie Woo
    98 Woo