Is % Δ SUVmax a useful indicator of survival in patients with advanced nonsmall-cell lung cancer? Journal Article
| Authors: | Cistaro, A.; Quartuccio, N.; Mojtahedi, A.; Fania, P.; Filosso, P. L.; Cucinotta, M.; Campenni, A.; Ficola, U.; Baldari, S. |
| Article Title: | Is % Δ SUVmax a useful indicator of survival in patients with advanced nonsmall-cell lung cancer? |
| Abstract: | Purpose. To investigate the impact of the maximum standardized uptake value (SUVmax), size of primary lung lesion, and %ΔSUVmax on outcome (overall survival (OS) and 2-year disease-free survival (2-year DFS)) of patients with advanced nonsmall-cell lung cancer (NSCLC). Materials and Methods. 86 stage III-IV NSCLC patients underwent 18 F-FDGPET/CT, before and after chemotherapy, and were classified into subgroups according to the response criteria of the European Organization for Research and Treatment of Cancer. SUVmax values and tumor size with the best prognostic significance were searched. Correlation between the SUVmax value and the initial response to therapy (best response) and the relationship between %ΔSUVmax and OS were assessed. Results. In patients in PD (20/86), the average pretreatment SUVmax was 11.8±5.23, and the mean size of the primary lesion was 43.35 mm±16.63. In SD, PR, and CR patients (66/86), the average pretreatment SUVmax was 12.7±8.05, and the mean size of the primary lesion was 41.6 mm±21.15. Correlation was identified only for %ΔSUVmax; patients with PD (ΔSUVmax > +25%) showed a worse OS than patients with ΔSUVmax < +25% (CR, PR, and SD) (P=0.0235). Conclusions. In stage III-IV NSCLC, among the assessed factors, only %ΔSUVmax may be considered as a useful prognostic factor. © 2013 Angelina Cistaro et al. |
| Keywords: | adult; cancer chemotherapy; cancer survival; treatment response; aged; survival rate; major clinical study; overall survival; disease free survival; cancer staging; tumor volume; lung non small cell cancer; survival time; fluorodeoxyglucose f 18; computer assisted emission tomography; maximum standardized uptake value; medical parameters |
| Journal Title: | The Scientific World Journal |
| Volume: | 2013 |
| ISSN: | 1537-744X |
| Publisher: | The Scientific World Journal |
| Date Published: | 2013-10-09 |
| Start Page: | 910957 |
| Language: | English |
| DOI: | 10.1155/2013/910957 |
| PROVIDER: | scopus |
| PMCID: | PMC3817635 |
| PUBMED: | 24228017 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 December 2013" - "Source: Scopus" |
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