Comparison of tumor volumes as determined by pathologic examination and FDG-PET/CT images of non-small-cell lung cancer: A pilot study Journal Article
| Authors: | Yu, J.; Li, X.; Xing, L.; Mu, D.; Fu, Z.; Sun, X.; Yang, G.; Zhang, B.; Ling, C. C. |
| Article Title: | Comparison of tumor volumes as determined by pathologic examination and FDG-PET/CT images of non-small-cell lung cancer: A pilot study |
| Abstract: | Purpose: To determine the cut-off standardized uptake value (SUV) on <sup>18</sup>F fluoro-2-deoxy-glucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) images that generates the best volumetric match to pathologic gross tumor volume (GTV<sub>path</sub>) for non-small-cell lung cancer (NSCLC). Methods and Materials: Fifteen patients with NSCLC who underwent FDG-PET/CT scans followed by lobectomy were enrolled. The surgical specimen was dissected into 5-7-μm sections at approximately 4-mm intervals and stained with hematoxylin and eosin. The tumor-containing area was outlined slice by slice and the GTV<sub>path</sub> determined by summing over all the slices, taking into account the interslice thickness and fixation-induced volume reduction. The gross tumor volume from the PET images, GTV<sub>PET</sub>, was determined as a function of cut-off SUV. The optimal threshold or optimal absolute SUV was defined as the value at which the GTV<sub>PET</sub> was the same as the GTV<sub>path</sub>. Results: The fixation process induced a volumetric reduction to 82% ± 10% (range, 62-100%) of the original. The maximal SUV was 10.1 ± 3.6 (range, 4.2-18.7). The optimal threshold and absolute SUV were 31% ± 11% and 3.0 ± 1.6, respectively. The optimal threshold was inversely correlated with GTV<sub>path</sub> and tumor diameter (p < 0.05), but the optimal absolute SUV had no significant correlation with GTV<sub>path</sub> or tumor diameter (p > 0.05). Conclusion: This study evaluated the use of GTV<sub>path</sub> as a criterion for determining the optimal cut-off SUV for NSCLC target volume delineation. Confirmatory studies including more cases are being performed. © 2009 Elsevier Inc. |
| Keywords: | adult; clinical article; controlled study; aged; middle aged; surgical technique; radiation dose; positron emission tomography; diagnostic accuracy; prospective studies; radiopharmaceuticals; tumor localization; tumor volume; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; tomography, x-ray computed; pathology; diagnostic imaging; dissection; diagnostic value; tumors; pilot study; pilot projects; tumor burden; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; positron-emission tomography; tumor volumes; glucose; eosin; hematoxylin; lobectomy; biological organs; fluorodeoxyglucose; non-small-cell lung cancer; cone beam computed tomography; optimization; pathologic tumor volume; pet/ct imaging; standardized uptake value; cut-off; fixation process; gross tumor volume; non small cell lung cancer; optimal threshold; pet images; pilot studies; positron emission tomography/computed tomographies; standardized uptake values; surgical specimens; target volume delineation; volume reductions |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 75 |
| Issue: | 5 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-12-01 |
| Start Page: | 1468 |
| End Page: | 1474 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2009.01.019 |
| PUBMED: | 19464822 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: IOBPD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work