Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT Journal Article
| Authors: | Gu, J.; Khong, P. L.; Wang, S.; Chan, Q.; Law, W.; Zhang, J. |
| Article Title: | Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT |
| Abstract: | Purpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010. |
| Keywords: | adult; clinical article; controlled study; aged; aged, 80 and over; middle aged; primary tumor; magnetic resonance imaging; image analysis; tumor volume; clinical assessment; body weight; standardization; quantitative analysis; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; cell density; rectum carcinoma; rectal neoplasms; diffusion weighted imaging; glycolysis; diffusion coefficient; correlational study; pet/ct; metabolic activation; suv; adc; dwi; primary rectal adenocarcinoma; tdi; tlg; positron-emission tomography and computed tomography |
| Journal Title: | Molecular Imaging and Biology |
| Volume: | 13 |
| Issue: | 5 |
| ISSN: | 1536-1632 |
| Publisher: | Springer |
| Date Published: | 2011-01-01 |
| Start Page: | 1020 |
| End Page: | 1028 |
| Language: | English |
| DOI: | 10.1007/s11307-010-0433-7 |
| PROVIDER: | scopus |
| PUBMED: | 20872077 |
| PMCID: | PMC3179585 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 1 March 2012" - "CODEN: CPIMF" - "Source: Scopus" |
