Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database Journal Article
| Authors: | Abou-Nassar, K. E.; Vanderplas, A.; Friedberg, J. W.; Abel, G. A.; Niland, J.; Rodriguez, M. A.; Czuczman, M. S.; Millenson, M.; Crosby, A.; Gordon, L. I.; Zelenetz, A. D.; Kaminski, M.; LaCasce, A. S. |
| Article Title: | Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database |
| Abstract: | We describe the patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for the initial staging of patients with newly diagnosed grade 1-2 follicular lymphoma (FL) and its potential impact on treatment. Data were obtained from the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database. Patients who presented between 1 January 2001 and 30 September 2009 with newly diagnosed grade 1-2 FL, with at least 6 months of follow-up, were included. We identified 953 eligible patients and 532 (56%) underwent FDG-PET as part of initial staging. Among patients who underwent FDG-PET for initial staging, 438 (82%) received early treatment compared to 259 (61.5%) of those staged without FDG-PET (p < 0.0001). Of all patients with stage I FL (n = 100), 47% were treated with radiotherapy (RT) alone, and the choice of initial treatment strategy for stage I FL did not vary significantly by use of FDG-PET (p = 0.22). The use of FDG-PET for staging of FL is widespread and is associated with a greater proportion of patients receiving early therapy. Given the widespread use and high cost of FDG-PET, its clinical utility in stage I FL should be further evaluated. © 2013 Informa UK, Ltd. |
| Keywords: | adult; aged; major clinical study; treatment duration; cancer radiotherapy; cancer staging; positron emission tomography; follow up; staging; cancer grading; bone marrow biopsy; fluorodeoxyglucose f 18; computer assisted radiotherapy; follicular lymphoma; fdg-pet imaging |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 54 |
| Issue: | 10 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2013-10-01 |
| Start Page: | 2155 |
| End Page: | 2162 |
| Language: | English |
| DOI: | 10.3109/10428194.2013.770151 |
| PROVIDER: | scopus |
| PUBMED: | 23343180 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):1 - "Export Date: 1 October 2013" - "CODEN: LELYE" - "Source: Scopus" |
