The role of PET in lymphoma Journal Article
| Authors: | Jhanwar, Y. S.; Straus, D. J. |
| Article Title: | The role of PET in lymphoma |
| Abstract: | Malignant lymphomas are a heterogeneous group of diseases whose treatment and prognosis depend on accurate staging and evaluation of histologic features. The conventional imaging procedure is CT; however, nuclear medicine imaging has also had a prominent role. Single-photon imaging with 67Ga-citrate has been widely used for lymphomas. PET with 18F-FDG has gained a role in the staging and follow-up of lymphomas, largely replacing gallium as the nuclear medicine study of choice. 18F-FDGPET has proved useful in the staging and follow-up of Hodgkin's disease and non-Hodgkin's lymphoma(especiallymore aggressive types), and the widespread use of PET/CT has also increased the sensitivity and specificity. Its usefulness for the staging of slow-growing lymphomas has not been established. After the basics of staging and classification of lymphomas have been outlined, this article will review the role of 18F-FDG PET in the management of patients with lymphoma. PET tracers other than 18F-FDG, such as positron-emitting isotopes of gallium and the cellular proliferation marker 18F-3′-deoxy- 3′-fluorothymidine, will be discussed and future directions for PET in lymphoma proposed. Copyright © 2006 by the Society of Nuclear Medicine, Inc. |
| Keywords: | cancer chemotherapy; treatment outcome; treatment response; disease course; review; drug efficacy; cancer radiotherapy; ibritumomab tiuxetan; cancer staging; outcome assessment; positron emission tomography; follow up; methodology; antineoplastic agent; neoplasm staging; diagnostic accuracy; sensitivity and specificity; cell proliferation; computer assisted tomography; multiple cycle treatment; diagnosis, differential; differential diagnosis; tomography, x-ray computed; diagnostic imaging; oncology; hodgkin disease; disease severity; nonhodgkin lymphoma; diagnostic agent; drug mechanism; diagnostic value; lymphoma, non-hodgkin; lymphoma; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; clinical evaluation; medical oncology; nuclear medicine; tumor growth; image processing, computer-assisted; image processing; gallium citrate ga 67; pet; tumor classification; tositumomab; gallium; hodgkin's disease; gallium radioisotopes; 67ga-citrate |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 47 |
| Issue: | 8 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2006-08-01 |
| Start Page: | 1326 |
| End Page: | 1334 |
| Language: | English |
| PUBMED: | 16883013 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 57" - "Export Date: 4 June 2012" - "CODEN: JNMEA" - "Source: Scopus" |
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