The winding pathway to erythropoietin along the chemistry-biology frontier: A success at last Journal Article
| Authors: | Wilson, R. M.; Dong, S.; Wang, P.; Danishefsky, S. J. |
| Article Title: | The winding pathway to erythropoietin along the chemistry-biology frontier: A success at last |
| Abstract: | The total synthesis of a homogeneous erythropoietin (EPO), possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of N glycosylation, has been accomplished in our laboratory. We provide herein an account of our decade-long research effort en route to this formidable target compound. The optimization of the synergy of the two bedrock sciences we now call biology and chemistry was central to the success of the synthesis of EPO. Going native: The total synthesis of a homogeneous erythropoietin, possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of N glycosylation, has been accomplished. Herein is an account of the decade-long research effort en route to this formidable target compound. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keywords: | review; molecular genetics; metabolism; erythropoietin; amino acid sequence; molecular sequence data; glycosylation; wild types; amino acid; esterification; chemical structure; molecular structure; polysaccharide; amino acids; polysaccharides; glycoproteins; glycoprotein; synthesis; total synthesis; synthesis (chemical); synthetic methods; erythropoietin (epo); n-glycosylation; research efforts; target compound |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 52 |
| Issue: | 30 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2013-07-22 |
| Start Page: | 7646 |
| End Page: | 7665 |
| Language: | English |
| DOI: | 10.1002/anie.201301666 |
| PROVIDER: | scopus |
| PUBMED: | 23775885 |
| PMCID: | PMC4729195 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: ACIEF" - "Source: Scopus" |
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