Toward homogeneous erythropoietin: Application of metal-free dethiylation in the chemical synthesis of the Ala79-Arg166 glycopeptide domain Journal Article

   


Authors: Dong, S.; Shang, S.; Tan, Z.; Danishefsky, S. J.
Article Title: Toward homogeneous erythropoietin: Application of metal-free dethiylation in the chemical synthesis of the Ala79-Arg166 glycopeptide domain
Abstract: We describe herein the assembly of hEPO(79-166), a key glycopeptide segment en route to erythropoietin, in minimally protected form. Key to the success of this synthetic endeavor was the application of our two-step cysteine-free native chemical ligation strategy, by which we achieved formal ligation at alanine and proline residues through the use of an N-terminal amino acid surrogate presenting a readily removable thiol functionality. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords: erythropoietin; glycoproteins; total synthesis; ligation; dethiylation
Journal Title: Israel Journal of Chemistry
Volume: 51
Issue: 8-9
ISSN: 0021-2148
Publisher: Wiley Blackwell  
Date Published: 2011-11-01
Start Page: 968
End Page: 976
Language: English
DOI: 10.1002/ijch.201100077
PROVIDER: scopus
PMCID: PMC3622263
PUBMED: 23585694
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-80155172883&partnerID=40&md5=832862b987b74e8056f97e0cf7e6c54a
Notes: --- - "Export Date: 9 December 2011" - "Source: Scopus"
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MSK Authors
  1. Zhongping Tan
    15 Tan
  2. Shiying Shang
    9 Shang
  3. Samuel J Danishefsky
    539 Danishefsky
  4. Suwei Dong
    8 Dong
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