Insights into the finer issues of native chemical ligation: An approach to cascade ligations Journal Article
| Authors: | Tan, Z.; Shang, S.; Danishefsky, S. J. |
| Article Title: | Insights into the finer issues of native chemical ligation: An approach to cascade ligations |
| Abstract: | Maximizing by minimizing: An efficient and broadly useful two-step ligation protocol was developed. Important mechanistic issues of ligation were probed from competition studies on the formation of diastereomeric ligation products. This study provides a valuable approach to facilitate polypeptide synthesis by minimizing protecting group manipulations and intermediate isolations. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keywords: | peptides; amino acids; leucine; desulfurization; native chemical ligation; surgical equipment; optimization; diastereomeric; kinetic control; protecting group |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 49 |
| Issue: | 49 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-12-03 |
| Start Page: | 9500 |
| End Page: | 9503 |
| Language: | English |
| DOI: | 10.1002/anie.201005513 |
| PROVIDER: | scopus |
| PMCID: | PMC3199326 |
| PUBMED: | 21053233 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: ACIEA" - "Source: Scopus" |
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