Advances in proline ligation Journal Article

   


Authors: Townsend, S. D.; Tan, Z.; Dong, S.; Shang, S.; Brailsford, J. A.; Danishefsky, S. J.
Article Title: Advances in proline ligation
Abstract: Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer. © 2012 American Chemical Society.
Keywords: amino terminal sequence; alkylation; amino acids; oxidation; chemical reaction; synthesis; glycopeptide; native chemical ligation; proline; chemical modification; diastereoisomer; dimer; n-terminals; dimers; proline derivative; selenolanthionine
Journal Title: Journal of the American Chemical Society
Volume: 134
Issue: 8
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2012-02-29
Start Page: 3912
End Page: 3916
Language: English
DOI: 10.1021/ja212182q
PROVIDER: scopus
PMCID: PMC3306728
PUBMED: 22332757
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84857739989&partnerID=40&md5=99a2df9346827b75d822a3315264d865
Notes: --- - "Export Date: 2 April 2012" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Zhongping Tan
    15 Tan
  2. Shiying Shang
    9 Shang
  3. Samuel J Danishefsky
    539 Danishefsky
  4. Suwei Dong
    8 Dong
  5. John Brailsford
    7 Brailsford
  6. Steven D Townsend
    9 Townsend
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