An advance in proline ligation Journal Article

   


Authors: Shang, S.; Tan, Z.; Dong, S.; Danishefsky, S. J.
Article Title: An advance in proline ligation
Abstract: Native chemical ligation (NCL) is widely applicable for building proteins in the laboratory. Since the discovery of this method, many strategies have been developed to enhance its capability and efficiency. Because of the poor reactivity of proline thioesters, ligation at a C-terminal proline site is not readily accomplished. Here, we demonstrate that ligation at an N-terminal protein is feasible using the combined logic of NCL and metal-free dethiylation (MFD). © 2011 American Chemical Society.
Keywords: metal-free dethiylation reaction
Journal Title: Journal of the American Chemical Society
Volume: 133
Issue: 28
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2011-07-20
Start Page: 10784
End Page: 10786
Language: English
DOI: 10.1021/ja204277b
PROVIDER: scopus
PMCID: PMC3135777
PUBMED: 21696220
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79960228639&partnerID=40&md5=2010700c09b101a4f42be475397089f9
Notes: --- - "Export Date: 17 August 2011" - "CODEN: JACSA" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Zhongping Tan
    15 Tan
  2. Shiying Shang
    9 Shang
  3. Samuel J Danishefsky
    539 Danishefsky
  4. Suwei Dong
    8 Dong
Related MSK Work