Promising agents at the interface of biology and oncology derived through chemical synthesis Journal Article


Authors: Wilson, R. M.; Danishefsky, S. J.
Article Title: Promising agents at the interface of biology and oncology derived through chemical synthesis
Abstract: This account traces the development of our synthetic glycopeptide- and glycoprotein-based research program over the past decade. We recount the syntheses of a number of biologically relevant, natural product-inspired glycopeptide constructs, including those associated with prostate specific antigen (PSA) and with the gp120 surface envelope protein of HIV. We also describe our progress toward the synthesis of the multiply glycosylated protein, erythropoietin (EPO). Particular emphasis is placed on the development of enabling methodologies which allow for the ligation of complex glycopeptide fragments, thus rendering it possible to access, through purely synthetic means, homogeneous, multidomainal glycopeptide and glycoprotein constructs. © 2007 IUPAC.
Keywords: erythropoietin; glycoproteins; synthesis; carbohydrates; glycopeptides; ligation
Journal Title: Pure and Applied Chemistry
Volume: 79
Issue: 12
ISSN: 0033-4545
Publisher: Walter de Gruyter GmbH  
Date Published: 2007-12-01
Start Page: 2189
End Page: 2216
Language: English
DOI: 10.1351/pac200779122189
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: PACHA" - "Source: Scopus"
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  1. Rebecca Wilson
    17 Wilson