Randomized clinical trials in melanoma Journal Article
| Authors: | Kingham, T. P.; Karakousis, G.; Ariyan, C. |
| Article Title: | Randomized clinical trials in melanoma |
| Abstract: | The incidence of melanoma is increasing and it is estimated that, in the United States, the lifetime risk of developing melanoma is 1 in 55. There have been many randomized trials that have refined the treatment and minimized the morbidity of the intervention of this prevalent disease. From 1975 to 2000, there were 154 prospective randomized trials on the treatment of local, regional, and metastatic melanoma. Between 2001 and the end of 2008, there were 52 randomized controlled trials relating to the treatment of patients with malignant melanoma. This article reviews the results of the major studies included in the prior article, and provides a detailed description of selected randomized controlled trials performed from 2001 to 2008. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; cancer surgery; surgical technique; clinical trial; fatigue; review; sorafenib; bevacizumab; cisplatin; interferon; drug efficacy; drug withdrawal; unspecified side effect; alpha interferon; adjuvant therapy; cancer adjuvant therapy; temozolomide; cancer staging; drug megadose; neurotoxicity; recurrence risk; lymph node metastasis; cancer incidence; lymph node dissection; sentinel lymph node biopsy; imatinib; alpha2b interferon; bcg vaccine; canvaxin; cytotoxic t lymphocyte antigen 4 antibody; dacarbazine; interleukin 2; peginterferon alpha2b; cancer immunotherapy; low drug dose; melanoma; controlled clinical trial; liver toxicity; multiple cycle treatment; randomized controlled trial; randomized controlled trials as topic; melphalan; carmustine; vinblastine; high risk patient; depression; randomized controlled trials; tamoxifen; mental disease; alpha2a interferon; management; mood disorder; tumor necrosis factor; qs 21; melanoma vaccine; methisoprinol; peginterferon |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 13 |
| End Page: | 31 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.09.008 |
| PUBMED: | 19914558 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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